G1P3 (IFI6), a Mitochondrial Localized Antiapoptotic Protein, Promotes Metastatic Potential of Breast Cancer Cells through mtROS
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PROVIDER: PRJNA453999 | ENA |
REPOSITORIES: ENA
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Project description:G1P3 (IFI6) was associated with poor distance metastasis free survival (DMFS) in breast cancer cases. Therefore, we tested the hypothesis that G1P3-induced mitochondrial redox deregulation confers metastatic potentials in breast cancer cells. Our results demonstrate that coordinated action of multiple pathways elicited by G1P3-induced mtROS augment actin-containing migratory structures to promote breast cancer cell migration and invasion Comparative network analysis identified upregulation of antioxidant, acin remodeling, and EMT networks in G1P3 overexpressing MCF-7 cells.
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