Genomics

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Transcriptome analysis of Meg3 KD and IG-DMR maternal deletion in ESC, pMN, and MN


ABSTRACT: Transcriptome analysis of Meg3 KD and IG-DMR maternal deletion in ESC, pMN, and MN

PROVIDER: PRJNA470618 | ENA |

REPOSITORIES: ENA

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The mammalian imprinted Dlk1-Dio3 locus produces multiple long non-coding RNAs (lncRNAs) from the maternally inherited allele, including Meg3 (i.e., Gtl2) in the mammalian genome. Although this locus has well-characterized functions in stem cell and tumor contexts, its role during neural development is unknown. By profiling cell types at each stage of embryonic stem cell-derived motor neurons (ESC~MNs) that recapitulate spinal cord development, we uncovered that lncRNAs expressed from the Dlk1-D  ...[more]

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