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MRNA-seq comparison of C. elegans L1 larvae with parents experiencing dietary restriction or ad libitum conditions

ABSTRACT: mRNA-seq comparison of C. elegans L1 larvae with parents experiencing dietary restriction or ad libitum conditions

PROVIDER: PRJNA470727 | ENA |

REPOSITORIES: ENA

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mRNA-seq comparison of C. elegans L1 larvae with parents experiencing dietary restriction or ad libitum conditions

Project description:Well-fed N2 worms were bleached as adults and embryos were placed in liquid culture under ad libitum (AL) or dietary restriction (DR) conditions. After 96 hr, AL and DR adults were bleached. AL and DR progeny were collected for mRNA-seq as starved L1 larvae

2018-11-01 | GSE114271 | GEO

mRNA-seq comparison of L1 larvae experiencing osmotic and starvation-induced arrest

Project description:Wild-type (N2) C. elegans embryos were plated with or without E. coli OP50 as food and with 100mM or 500mM NaCl at 25C (4 conditions). They were allowed to develop for 24hr and collected as L1 larvae for RNA-seq.

2017-02-06 | GSE91039 | GEO

Effect of 20-Hete and dietary restriction on murine kidneys

Project description:Transcriptomic dataset of 15 murine kidneys of 14-week-old male C57Bl6 mice. Mice were divided into 3 treatment groups four weeks prior to nephrectomy and 5 mice had ad libitum (AL) access to food and water, while another 10 mice received 30% food restriction (CR). Calorically restricted mice either received intraperitoneal supplementation of 20-HETE (HETE) or vehicle (Veh, EtOH in sodiumchloride 0.9%) for 8 days on a daily basis prior to nephrectomy. Ad libitum fed mice received vehicle injections for 8 days on a daily basis prior to nephrectomy.

2022-05-10 | E-MTAB-11428 | biostudies-arrayexpress

Ageing liver RNAseq of C57BL/6 male mice in dietary restricted and an ad libitum diets

Project description:45 mice were fed constantly (Ad libitum; AL) while a second group of mice were fed 30% less from month 3 of age (Dietary restricted; DR). Tissues were collected from mice of all groups at 3 and 15 months of age. A group of mice from AL and DR at 12 months were moved to the opposite diet and sequenced at 15 months.

2017-05-04 | E-MTAB-5645 | biostudies-arrayexpress

Gene Expression Analysis of Fat Body of Drosophila melnaogaster subjected to Dietary restriction for certain time points

Project description:Dietary restriction is a nutritional intervention that consistently increases life span in animals. To identify alternative, more acceptable nutritional regimes that nevertheless extend life span, we used the fruit fly Drosophila melanogaster as a model. We tested if weekly recurring nutritional regimes composed of phases of ad libitum feeding and dietary restriction can increase life span. Short periods of dietary restriction (up to 2 days) followed by longer ad libitum phases increased life span only marginally, whereas regimes comprising longer contiguous periods (3 days and more) became clearly positive, reaching similar life span extensions as those seen if dietary restriction was applied persistently. Female flies were substantially more responsive to these interventions than males. The finding that a minimal period of 3-4 days of dietary restriction is required to induce robust life span extensions was mirrored by the observation that substantial physiological and transcriptional changes occurred in a similar temporal pattern. Moreover, these dietary restriction induced changes were also detectable after switching to ad libitum feeding. Among the physiological changes induced by these phases of dietary restriction, a reduced metabolic rate and a substantial and long-lasting reduction in insulin signaling were most compelling. Age associated molecular signatures comprising mechanisms that reduce insulin signaling showed up after longer periods of dietary restriction in the fly’s fat body, thus showing how molecular alterations transduce into life span related physiological changes.

2017-12-21 | GSE95349 | GEO

Nine-spined stickleback linkage map (parents)

Project description:Nine-spined stickleback linkage map (parents)

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Caloric restriction and rat fecal microbiota

Project description:Characterization of the fecal metaproteome in rats fed ad libitum or following a caloric restriction diet

2018-10-08 | PXD007252 | Pride

Microarray of liver from Red Junglefowl (Gallus gallus) raised on intermittent fasting, chronic 70% restriction or ad libitum feeding

Project description:To better understand the hepatic metabolic response to intermittent fasting in chickens, Red Junglefowl chickens were raised on ad libitum (AL) feed until 14 days of age and then kept on AL feeding, switched to chronic feed restriction (CR) to around 70% or switched to an intermittent fasting (IF) regimen consisting of two fed days (150% of age-matched weight-specific AL intake offered daily) followed by a non-fed day. AL and CR were culled at 36 days of age, and IF birds either at 40 days of age (second consecutive feeding day) or 41 days of age (fasting day).

2022-04-14 | E-MTAB-7829 | biostudies-arrayexpress

Role of DNA methylation in the dietary restriction mediated cellular memory

Project description:Dietary restriction (DR) appears to create a cellular memory, which persists even after DR is discontinued.DNA methylation seems a logical mechanism by which a cellular memory could be established.we first examined the effect of short-term DR on gene expression and DNA methylation, then determined whether the changes persisted after DR was discontinued and mice returned to ad libitum (AL) feeding.We show that DR can induce substantial changes in gene expression within one month of its implementation in various tissues, and ~15-50% of these changes in gene expression persist even when DR is discontinued. We then determined whether DR induced changes in DNA methylation in the promoter of three candidate genes (Pomc, Hsph1 and Nts1) that were correlated with the changes in the expression of these genes.

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Effects of ad libitum feeding on canine skeletal muscle gene expression

Project description:Skeletal muscle, as a large and insulin sensitive tissue, is an important contributor to metabolic homeostasis and energy expenditure. Obese dogs exhibit skeletal muscle insulin resistance, but the causes of these changes are unclear. Thus, we used canine microarrays to analyze gene expression profiles of skeletal muscle tissue collected from obese dogs, after 24 wk of ad libitum feeding. Skeletal muscle tissue samples were collected from 9 intact female beagles (4 yr-old; 4 control; 5 ad libitum) after 24 wk of ad libitum feeding.

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