Project description:In this study, the spleen deficiency syndrome rat model was built with reserpine injection method. At first, the intervention effect of SJZD on spleen deficiency syndrome was preliminary evaluation through pharmacodynamics study. By comparing the differences proteins of liver tissues by label-free proteomics techniques, the differentially expressed proteins of spleen deficiency syndrome and SJZD intervention spleen deficiency syndrome were screened. At last, differentially expressed proteins were analyzed with bioinformatics analysis method, the potential target proteins of spleen deficiency syndrome and SJZD intervention spleen deficiency syndrome were excavated. At the same time, the corresponding metabolic pathways and biological molecular interaction network was established. We hope to probe the mechanisms of SJZD intervention spleen deficiency syndrome from the aspect of proteomic to provide a scientific basis for the clinical diagnosis and treatment of spleen deficiency syndrome.
Project description:Interventions: Patients with spleen deficiency and qi stagnation syndrome SDQSS:NA;Patients with DHS with damp-heat accumulation syndrome:NA;Patients with SPOS with stasis and internal resistance syndrome:NA;Patients with SKYDS of Spleen and Kidney Yang Deficiency Syndrome:NA;Patients with liver-kidney yin deficiency syndrome LKYDS:NA;QBDS patients with deficiency of both qi and blood syndrome:NA
Primary outcome(s): Serum metabolites;Fecal microbiome;lipidomics
Study Design: Diagnostic test for accuracy
Project description:Interventions: Syndrome of spleen qi deficiency1:Chinese medicine of Supplementing Qi and nourishing spleen;Syndrome of spleen qi deficiency2:no;Flat syndrome group:no;Qi deficiency constitution:no
Primary outcome(s): Symptom score;Serum TTR expression
Study Design: Case-Control study
Project description:Bioavailability of isoflavone metabolites after Korean fermented soybean paste (Doenjang) ingestion in estrogen deficiency-induced rats
