Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Paternal malnutrition programs offspring’s breast cancer risk and tumor metabolism in a mouse model (MBD-seq)

ABSTRACT: Paternal malnutrition programs offspring’s breast cancer risk and tumor metabolism in a mouse model (MBD-seq)

PROVIDER: PRJNA471326 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Paternal malnutrition programs offspring’s breast cancer risk and tumor metabolism in a mouse model

Project description:Paternal malnutrition programs offspring’s breast cancer risk and tumor metabolism in a mouse model

| PRJNA471320 | ENA

Paternal malnutrition programs offspring’s breast cancer risk and tumor metabolism in a mouse model (small RNA-seq)

Project description:Paternal malnutrition programs offspring’s breast cancer risk and tumor metabolism in a mouse model (small RNA-seq)

| PRJNA471323 | ENA

Paternal malnutrition programs offspring’s breast cancer risk and tumor metabolism in a mouse model (MBD-seq)

Project description:We found that LP daughters have lower birthweight, alterations in mammary gland morphology and higher rates of mammary cancer. Further, we found that mammary glands and tumors of LP daughters are metabolic rewired, with alterations in the AMPK and amino-acid metabolism pathways. These changes were associated with differential expression of miRNAs 451a, miR-200c and miR-92a. Importantly, some of the same miRNAs and target genes alterations were detected in breast tumors of women from populations with high rates of low birthweight.

2018-06-14 | GSE114422 | GEO

Paternal malnutrition programs breast cancer risk and tumor metabolism in offspring.

Project description: Not available

| S-EPMC6117960 | biostudies-literature

Paternal malnutrition programs offspring’s breast cancer risk and tumor metabolism in a mouse model

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-06-14 | GSE114423 | GEO

Microbes Malnutrition Microglia

Project description:Microbes Malnutrition Microglia

| PRJNA575001 | ENA

Transcriptomic analysis of paternal behaviors in prairie voles

Project description:The importance of fathers' engagement in care and its critical role in the offspring’s cognitive and emotional development is now well established. Yet, little is known on the underlying neurobiology due to the lack of appropriate animal models. In the socially monogamous and bi-parental prairie vole (Microtus ochrogaster), while most virgin males show spontaneous paternal behaviors (Paternal), others display pup-directed aggression (Attackers). Here we took advantage of this phenotypic dichotomy and used RNA-sequencing in three important brain areas to characterize gene expression associated with paternal behaviors of Paternal males and compare it to experienced fathers and mothers. This strategy allowed the identification of spontaneous paternal behaviors independently from fatherhood and pair-bonding. While Paternal males displayed the same range and extent of paternal behaviors than experienced Fathers, the nucleus accumbens (NAc) and medial preoptic area (MPOA) transcriptomes mainly reflected pair-bonded status or sex differences, respectively. The lateral septum (LS) transcriptome, however, primarily reflected phenotypic differences between Paternal and Attackers and suggested the involvement of the mitochondria, RNA translation, and protein degradation processes. Altogether, these observations highlight a marked structure- and phenotype-specific pattern of gene expression underlying paternal behaviors in prairie voles and highlight similarities and differences from those underlying fatherhood.

2022-10-05 | GSE190213 | GEO

Paternal malnutrition programs offspring’s breast cancer risk and tumor metabolism in a mouse model (small RNA-seq)

2018-06-14 | GSE114421 | GEO

Epigenetic Analysis of Malnutrition

Project description:Epigenetic Analysis of Malnutrition

| PRJNA312717 | ENA

Malnutrition during lactation programs the hypothalamic gene networks controlling reproductive function through generations

Project description:The timing of pubertal initiation and progression in mammals is likely influenced by the nutritional and metabolic state, leading us to the hypothesis that transient malnutrition experienced at critical times during development may contribute to alterations in the rate of pubertal progression through generations. Accordingly, using a mouse model of lactation under-nutrition during suckling, we predicted that body composition, reproductive performance parameters and expression of genes responsible for hypothalamic neural circuits controlling among others reproductive function will be changed in F1 and F2 offspring.

2016-05-04 | GSE72746 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data