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Gene expression profiling of tumors harvested from mice exhibiting diet-induced obesity (DIO mice) relative to lean control mice (control mice)

ABSTRACT: Gene expression profiling of tumors harvested from mice exhibiting diet-induced obesity (DIO mice) relative to lean control mice (control mice)

PROVIDER: PRJNA471897 | ENA |

REPOSITORIES: ENA

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Gene expression profiling of tumors harvested from mice exhibiting diet-induced obesity (DIO mice) relative to lean control mice (control mice)

Project description:Gene expression profiling by microarray analysis of tumors formed from inoculation of the established human breast cancer cell line MDA-MB-468 in two groups of mice: lean control and DIO mice.

2019-01-16 | GSE114604 | GEO

Transcriptomic analysis of circumvallate papillae (CVP) from lean and DIO mice

Project description:Diet-induced obesity (DIO) is associated with a decreased oral fat detection in rodents. This blunted gustatory detection has been explained by an impairment of the lipid-mediated signaling in taste bud cells (TBC). However, factors responsible for this defect remain elusive. To better understand the mechanisms involved, circumvallate papillae from Lean, DIO and former DIO mice were analyzed with a transcriptomic approach. [using Agilent Sureprint G3 Mouse microarrays (8x60K, design 028005)]

2018-03-13 | GSE111719 | GEO

Integrated analysis of lncRNA and mRNA expression profiles in the submandibular glands of DIO mice

Project description:Objective: Obesity contributes to the dysfunction of salivary gland. To explore the specific underlying mechanism for obesity-induced hyposalivation, a model for high-fat diet-induced obese (DIO) mice were constructed to analyze long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) expression profiles. Methods: The DIO group and control group were fed a diet containing 60 kcal% fat and a normal chow diet for 16 weeks respectively. Microarray analyses were performed to detect the expression profiles of lncRNA and mRNA in submandibular gland tissues from control group mice and DIO mice. Gene ontology, kyoto encyclopedia of genes and genomes, protein-protein interaction, coding-non-coding gene co-expression, transcription factors and competing endogenous RNA analyses were performed to examine the function of differential expressed genes. Results: The microarray identified that 624 lncRNAs, along with 297 mRNAs were differentially expressed. Bioinformatic analyses revealed that “complement and coagulation cascades”, “glutathione metabolism”, “cysteine and methionine metabolism”, and “estrogen signaling pathway” were significantly associated with candidate lncRNAs, transcription factors analysis on candidate lncRNAs reveled several genes such as tribbles pseudokinase 3 may play regulatory roles. Conclusions: Our results revealed the expression profiles of lncRNAs and mRNAs and provided new insights into the mechanism of obesity-induced hyposalivation using bioinformatic analyses.

2020-12-31 | GSE162953 | GEO

Hypothalamus of diet-induced obese (DIO) mice treated with celastrol or DMSO

Project description:Since leptin signaling in the hypothalamus is critical to regulate food intake and body weight, we investigated how celastrol alters the hypothalamic transcriptome of DIO mice. By doing this analysis, genes with potential relevance for celastrol-mediated leptin sensitization could be identified.

2018-12-27 | GSE124353 | GEO

Tissue transcriptome atlas across DIO and lean mouse tissues

Project description:RNA sequencing was performed on several tissues extracted from 5 lean and 5 diet-induced obese (DIO) mice.

2021-10-13 | GSE185466 | GEO

Gene expression in diet-induced obesity resistent (DIO non-responder) and diet-induced obesity susceptible (DIO responder) C57BL/6J mouse strain

Project description:Inbred C57BL/6J mice differ in their susceptibility to diet-induced obesity. Comparison of the liver transcriptomes leads to genes that are involved in the development as well as the maintenance of fatty liver during the onset of obesity upon high fat diet feeding. Genes being upregulated in DIO responder can be seen as drivers of fatty liver development, while genes upregulated in DIO non-responder are most likely involved in the protection against fatty liver diseases.

2018-10-30 | GSE74542 | GEO

MicroRNA profiling of mouse epididymal adipocytes from control and diet-induced obese mice

Project description:Compare miRNA expression profiles in epididymal adipocytes from control and diet-induced obese (DIO) mice

2009-02-25 | E-MEXP-1932 | biostudies-arrayexpress

Transcriptomic analysis of circumvallate papillae (CVP) from lean and DIO mice

Project description:Transcriptomic analysis of circumvallate papillae (CVP) from lean and DIO mice

| PRJNA437960 | ENA

Hypothalamus of diet-induced obese (DIO) mice treated with celastrol or DMSO

Project description:Hypothalamus of diet-induced obese (DIO) mice treated with celastrol or DMSO

| PRJNA511818 | ENA

RNAseq of liver harvested from CDAHFD mice treated for 8 weeks with either the MGAT2 inhibitor compound BMS-963272 or vehicle

Project description:This experiment consists of RNAseq of liver harvested from CDAHFD mice treated for 8 weeks with either the MGAT2 inhibitor compound BMS-963272 (N = 10) or with vehicle (N = 10).

| EGAS00001006583 | EGA

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