Genomics

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Long non-coding RNAs discriminate the stages and gene regulatory states of the human humoral immune response


ABSTRACT: Long non-coding RNAs discriminate the stages and gene regulatory states of the human humoral immune response

PROVIDER: PRJNA472701 | ENA |

REPOSITORIES: ENA

Dataset's files

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Action DRS
SRR7207585.fastq.gz Fastqsanger.gz
SRR7207586.fastq.gz Fastqsanger.gz
SRR7207587.fastq.gz Fastqsanger.gz
SRR7207588.fastq.gz Fastqsanger.gz
SRR8643954.fastq.gz Fastqsanger.gz
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Publications

Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response.

Agirre Xabier X   Meydan Cem C   Jiang Yanwen Y   Garate Leire L   Doane Ashley S AS   Li Zhuoning Z   Verma Akanksha A   Paiva Bruno B   Martín-Subero José I JI   Elemento Olivier O   Mason Christopher E CE   Prosper Felipe F   Melnick Ari A  

Nature communications 20190218 1


lncRNAs make up a majority of the human transcriptome and have key regulatory functions. Here we perform unbiased de novo annotation of transcripts expressed during the human humoral immune response to find 30% of the human genome transcribed during this process, yet 58% of these transcripts manifest striking differential expression, indicating an lncRNA phylogenetic relationship among cell types that is more robust than that of coding genes. We provide an atlas of lncRNAs in naive and GC B-cell  ...[more]

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