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TAF1 is critical for AE driven leukemogenesis [RNA-seq]

ABSTRACT: TAF1 is critical for AE driven leukemogenesis [RNA-seq]

PROVIDER: PRJNA473831 | ENA |

REPOSITORIES: ENA

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TAF1 is critical for AE driven leukemogenesis [RNA-seq]

Project description:TAF1 is essential for AE driven leukemogenesis. Depletion of TAF1 impairs the recruitment of AE to its target genes, interfering with its control of gene expression. The bromodomains of TAF1 associate with K43 acetylated AE and this association plays a role in the proliferation of AE expressing AML cells.

2019-09-11 | GSE115121 | GEO

TAF1 is critical for AE driven leukemogenesis [ChIP-seq]

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TAF1 is critical for AE driven leukemogenesis [ATAC-seq]

Project description:TAF1 is essential for AE driven leukemogenesis. Depletion of TAF1 impairs the recruitment of AE to its target genes, interfereing with its control of gene expression. The bromodomains of TAF1 associate with K43 acetylated AE and this association plays a role in the proliferationof AE expressing AML cells.

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TAF1 is critical for AE driven leukemogenesis

Project description:TAF1 is critical for AE driven leukemogenesis

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Project description:TAF1 is critical for AE driven leukemogenesis [ATAC-seq]

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TAF1 is critical for AE driven leukemogenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

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TAF1 plays a critical role in AML1-ETO driven leukemogenesis.

Project description: Not available

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Genome-wide transcriptional dependencies on TAF1 functional domains

Project description:TFIID plays a central role in regulating the expression of most eukaryotic genes. Of the 14 TAF subunits that compose TFIID, TAF1 is one of the largest and most functionally diverse. Yeast (Saccharomyces cerevisiae) TAF1 reportedly possesses at least four distinct activities including a histone acetyltransferase, and TBP, TAF, and promoter binding. Establishing the importance of each region in gene expression through deletion analysis has been hampered by the cellular requirement of TAF1 for viability. To circumvent this limitation we introduced galactose-inducible deletion derivatives of previously defined functional regions of TAF1 into a temperature sensitive taf1ts2 yeast strain. After galactose-induction and temperature inactivation of the temperature-sensitive allele, we examined the properties and phenotypes of the mutants, including their impact on genome-wide transcription. Virtually all TAF1-dependent genes, which comprise ~90% of the yeast genome, displayed a strong dependency upon all regions of TAF1 that were tested. This might reflect the need for each region of TAF1 to stabilize TAF1 against degradation or that all TAF1-dependent genes require the many activities of TAF1. Paradoxically, deletion of the region of TAF1 that is important for promoter binding interfered with the expression of many genes that are normally TFIID-independent/SAGA-dominated, suggesting that this region normally prevents TAF1 (TFIID) from interfering with the expression of SAGA-regulated genes. Keywords: genetic modification

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Ae. aegypti and Ae. albopictus

Project description:The mosquito vectors Ae. aegypti and Ae. albopictus Targeted loci

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