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Translational regulation of RANKL by CPEB2 regulates mammary gland development and luminal tumorigenesis

ABSTRACT: Translational regulation of RANKL by CPEB2 regulates mammary gland development and luminal tumorigenesis

PROVIDER: PRJNA473999 | ENA |

REPOSITORIES: ENA

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Translational regulation of RANKL by CPEB2 regulates mammary gland development and luminal tumorigenesis (RIP-seq)

Project description:Translational regulation of RANKL by CPEB2 regulates mammary gland development and luminal tumorigenesis (RIP-seq)

| PRJNA474001 | ENA

Translational regulation of RANKL by CPEB2 regulates mammary gland development and luminal tumorigenesis (Affymetrix Microarrays)

Project description:Translational regulation of RANKL by CPEB2 regulates mammary gland development and luminal tumorigenesis (Affymetrix Microarrays)

| PRJNA474002 | ENA

Translational regulation of RANKL by CPEB2 regulates mammary gland development and luminal tumorigenesis (RIP-seq)

Project description:Here we show that the RNA-binding protein CPEB2 controls synthesis of RANKL, thereby modulating epithealial proliferation, differentiation and breast cancer outcome

2020-05-28 | GSE115174 | GEO

Translational regulation of RANKL by CPEB2 regulates mammary gland development and luminal tumorigenesis (Affymetrix Microarrays)

Project description:Here we show that the RNA-binding protein CPEB2 controls synthesis of RANKL, thereby modulating epithealial proliferation, differentiation and breast cancer outcome

2020-05-28 | GSE115173 | GEO

Translational regulation of RANKL by CPEB2 regulates mammary gland development and luminal tumorigenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-05-28 | GSE115175 | GEO

Regulation of mammary luminal cell differentiation and tumorigenesis by p38α

Project description:Mammary stem and progenitor cells are essential for mammary gland homeostasis and are also candidates for cells of origin of mammary tumors. Here, we provide evidence that the protein kinase p38a is required for the differentiation of luminal progenitor cells through modulation of the transcription factors Runx1 and Foxa1. Moreover, using a mouse model for breast cancer initiated by luminal cells, we show that p38a downregulation in mammary epithelial cells reduces tumorigenesis, which correlates with reduced numbers of tumor-initiating cells. Our results identify p38a as a key regulator of luminal progenitor cell fate that facilitates mammary tumor formation.

2017-12-28 | GSE92877 | GEO

RNAseq of mouse mammary luminal cells

Project description:The mammary epithelia are mainly composed of two distinct lineages, the basal and luminal cells. In our MMTV-Cre; Brca1flox/flox mouse model, we found the Brca1 knockout mainly occurred in the luminal cells, which will lead the mammary tumorigenesis. To investigate the Brca1 deficiency mediated mammary tumorigenesis, we sorted the luminal cells from wild type mice and MMTV-Cre; Brca1flox/flox mice for RNAseq analysis.

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A basal specific microRNA promotes tumorigenesis in both basal and luminal cells of murine prostate gland

Project description:Recent studies demonstrate both basal and luminal cells of the prostate gland can initiate tumorigenesis upon oncogenic transformation. However, it remains unclear how molecular mechanisms operating within each cell lineage contribute to the initiation and progression of the prostate cancer. Here we investigate functions of individual miRNAs using genetically engineered mouse models. By both quantitative miR-Seq and in situ hybridization, we identify microRNA-205 (miR-205) as the most highly expressed miRNA and specific to the basal cells in the prostate. MicroRNA-205 expression is further elevated in the basal cells in the well-established Pten null tumorigenic mouse model. To investigate the role of miR-205 in Pten-deletion mediated tumorigenesis, we generated a Pten/miR-205 double knockout mouse model. Concurrent deletion of both miR-205 and Pten significantly compromised tumor progression in both basal and luminal compartments. We observed significantly reduced tumor size and compromised proliferation in both basal and luminal cells. We have previously demonstrated a critical requirement of miR-205 for maintaining the PI(3)K signaling and pAkt levels in skin stem cells. Consistent with this role, we observed strong reduction of pAkt and significantly increased cellular senescence in the basal cells of the dKO, compared to the Pten KO alone. These results suggest that miR-205 is cell-autonomously required for the tumorigenesis of the basal cells. Taken together, we have identified miR-205 as an important regulator in prostate cancer. Our study also reveals an essential and unexpected role of the basal cells for promoting prostate tumorigenesis.

2019-09-16 | GSE75321 | GEO

Transcriptional signature of unipotent luminal progenitors of the mouse mammary gland

Project description:We report here the transcriptional signature of Notch1-expressing (GFP positive) luminal mammary progenitors compared to total luminal cells (GFP negative). For each condition, 3 biological replicates were performed, by pooling the mammary glands from two mice/replicate.

2015-01-04 | E-MTAB-2897 | biostudies-arrayexpress

Transcriptome analyses of luminal-derived basal cells induced by hormones in the mammary gland

Project description:We have used RNA-seq to examine RNA differential expression among three populations, normal basal cells, luminal-derived basal cells (LdBCs) and normal luminal cells.

2019-12-31 | GSE109543 | GEO

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