Project description:The rules of engagement between zinc finger transcription factors and DNA have been partly defined by in vitro DNA-binding and structural studies, but less is known about how these rules apply in vivo. Here we demonstrate how a missense point mutation in the second zinc finger of Krüppel-like factor-1 (KLF1) leads to degenerate DNA-binding specificity in vivo, resulting in ectopic transcription and semi-dominant neonatal anemia. We employed RNA-seq, ChIP-seq and 4sU-RNA-seq to identify the direct transcriptional consequences of aberrant DNA-binding events genome wide. Funding: National Health and Medical Research Council [APP1082429 to A.C.P.]; United States Public Health Service [R01 GM103544 to T.B., R01 DK100692 to L.L.P. and R01 DK46865 to J.J.B.]; Victorian Government Operational Infrastructure Support Scheme [St Vincent's Institute of Medical Research to M.W.P]. Funding for open access charge: Mater Research - UQ [APP1082429].
Project description:Pti5 is an ERF transcription factor that was differentially expressed in PVY-infected potato plants. The purpose of generating this dataset was to identify genes with perturbed expression due to silencing the Pti5 gene. Grant ID: P4-0165 Slovenian Research Agency ARRS Biotechnology and Plant Systems Biology Grant ID: J4-7636 Slovenian Research Agency ARRS Spatiotemporal analysis of hypersensitive response to Potato virus Y in potato Grant ID: J4-1777 Slovenian Research Agency ARRS Unraveling mechanisms of effectiveness and specificity in potato immune signaling through innovative data acquisition and modeling
Project description:To determine differences in GC Tfh cells isolated from the tonsils of children who have undergone tonsillectomy for either recurrent Group A Streptococcus (GAS) tonsillitis (RT) or non-RT (sleep apnea). Grants: Thrasher Research Fund for an Early Career Award 12969 - Jennifer Dan UM1 AI100663 - Shane Crotty Clinical Research Fellowship Grant UK Charity No. 1089464 - David Layfield, Ramsey Cuttress, Christian Ottensmeier
Project description:Oregon Health & Science University (OHSU) is the only comprehensive public academic health center in the state of Oregon. Its fundamental purpose is to improve the health and well being of people in Oregon and beyond. As part of its multifaceted public mission, OHSU strives for excellence in education, research and scholarship, clinical practice and community service. Through its dynamic interdisciplinary environment, OHSU stimulates the spirit of inquiry, initiative, and cooperation among students, faculty and staff
Project description:This SuperSeries is composed of the SubSeries listed below. Grant ID: Award No. W81XWH-16-1-0130 Grant title: Peer Reviewed Medical Research Program Funding Source: Assistant Secretary of Defense for Health Affairs Affiliation: Jackson Laboratory for Genomic Medicine, Farmington, CT Name: Michael Stitzel
Project description:In the present study molecular interactions between potato plants, Colorado potato beetle (CPB) larvae and Potato virus YNTN (PVYNTN) were investigated by analyzing gene expression in potato leaves. Grant ID: J4-4165 Slovenian Research Agency ARRS Growth and defense trade-offs in multitrophic interaction between potato and its two major pests Grant ID: P4-0165 Slovenian Research Agency ARRS Biotechnology and Plant Systems Biology
Project description:We sequenced the xylem transcriptome from a population of unrelated individuals of P. deltoides to uncover a master regulator of lignin biosynthesis. Grant ID: IOS-1444543 Grant Title: Genome and transcriptome based prediction, and regulator inference, o molecular and whole-plant phenotypes. Funding source: NSF Plant Genome Research Program.
2020-05-04 | GSE140232 | GEO
Project description:Public Science and Technology Research Funds Projects of Agriculture
