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Repeated social defeat stress (R-SDS)-induced changes in gene expression profiles in microglia or whole medial prefrontal cortex

ABSTRACT: Repeated social defeat stress (R-SDS)-induced changes in gene expression profiles in microglia or whole medial prefrontal cortex

PROVIDER: PRJNA476760 | ENA |

REPOSITORIES: ENA

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Repeated social defeat stress (R-SDS)-induced changes in gene expression profiles in the medial prefrontal cortex (mPFC)

Project description:Repeated social defeat stress (R-SDS)-induced changes in gene expression profiles in the medial prefrontal cortex (mPFC)

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Repeated social defeat stress (R-SDS)-induced changes in gene expression profiles in the medial prefrontal cortex (mPFC)

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Transcriptome analysis of microglia isolated from the mPFC or NAc without or with repeated social defeat stress (R-SDS)

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Microglial RNA-sequencing after stress-sensitization by repeated social defeat

Project description:Stress is associated with an increased prevalence of anxiety and depression. Repeated social defeat (RSD) stress in mice increases the release of monocytes from the bone marrow that are recruited to the brain by microglia. These monocytes enhance inflammatory signaling and augment anxiety. Moreover, RSD promotes stress sensitization, in which exposure to acute stress 24 days after cessation of RSD causes anxiety recurrence. The purpose of this study was to determine whether microglia were critical to stress sensitization and exhibited altered gene expression 24 days after RSD.

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Repeated social defeat stress (R-SDS)-induced changes in gene expression profiles in microglia or whole medial prefrontal cortex

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-08-09 | GSE115996 | GEO

Transcriptome analysis of microglia isolated from the mPFC or NAc without or with repeated social defeat stress (R-SDS)

Project description:Transcriptome analysis of microglia isolated from the mPFC or NAc without or with repeated social defeat stress (R-SDS)

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