Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

DNA methylation oscillations at CpG poor enhancers in primed embryonic stem cells [scRNA-Seq, scBS-Seq]

ABSTRACT: DNA methylation oscillations at CpG poor enhancers in primed embryonic stem cells [scRNA-Seq, scBS-Seq]

PROVIDER: PRJNA477527 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

DNA methylation oscillations at CpG poor enhancers in primed embryonic stem cells [amplicon-Seq]

Project description:Mouse embryonic stem cells (ESCs) primed for differentiation display dynamic heterogeneity characterised by stochastic switching between transcriptional states, and recent advances have highlighted the heterogeneous and dynamic nature of DNA methylation in these. Using single cell sequencing we report global oscillations in ESC DNA methylation that affect particularly CpG poor regions including distal enhancers. These oscillations are dependent on DNA methylation turnover by Dnmt3 and Tet enzymes and influence the probability of transcriptional state switching. Our observations suggest that regulated DNA methylation heterogeneity may contribute to lineage priming in cells poised for differentiation.

2018-06-26 | GSE116163 | GEO

DNA methylation oscillations at CpG poor enhancers in primed embryonic stem cells [PBAT Bisfulfite-seq]

2018-06-26 | GSE75973 | GEO

DNA methylation oscillations at CpG poor enhancers in primed embryonic stem cells [scRNA-Seq, scBS-Seq]

2018-06-26 | GSE116165 | GEO

DNA methylation oscillations at CpG poor enhancers in primed embryonic stem cells [amplicon-Seq]

Project description:DNA methylation oscillations at CpG poor enhancers in primed embryonic stem cells [amplicon-Seq]

| PRJNA477530 | ENA

DNA methylation oscillations at CpG poor enhancers in primed embryonic stem cells [single cell Bisulfite-seq]

2018-06-26 | GSE75974 | GEO

Mus musculus

Project description:DNA methylation oscillations at CpG poor enhancers in primed embryonic stem cells [Bisulfite-seq]

| PRJNA305882 | ENA

Mus musculus

Project description:DNA methylation oscillations at CpG poor enhancers in primed embryonic stem cells [PBAT Bisfulfite-seq]

| PRJNA305883 | ENA

Mus musculus

Project description:DNA methylation oscillations at CpG poor enhancers in primed embryonic stem cells [single cell Bisulfite-seq]

| PRJNA305884 | ENA

Rhythmic transcription drives mRNA level oscillations during C. elegans development [RNA-Seq]

Project description:Thousands of transcripts accumulate in an oscillatory manner during C. elegans larval development. Here, we performed total RNA sequencing to confirm and quantify transcript levels oscillations on samples that we used in parallel to probe rhythmic RNA polymerase II recruitment to these genes as a mechanism to generate RNA level oscillations (see parallel submission of ChIP-seq data)

2022-12-31 | GSE169640 | GEO

Global DNA CpG methylation profiling of human embryonic stem cells, fibroblast iPSC, and low passage stromal primed myeloid iPSC before and after conversion to the naïve state

Project description:Global DNA CpG methylation profiling of human embryonic stem cells, fibroblast iPSC, and low passage stromal primed myeloid iPSC before and after conversion to the naïve state

2016-09-13 | GSE65214 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data