Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Blood transcriptional profiles discriminates cerebral and mild malaria patient living in Senegal

ABSTRACT: Blood transcriptional profiles discriminates cerebral and mild malaria patient living in Senegal

PROVIDER: PRJNA478031 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Blood transcriptional profiles discriminates cerebral and mild malaria patient living in Senegal

Project description:PBMCs were obtain from mild malaria and cerebral malaria patient at the onset of P. falciparum infection. Patient recruitment took place in two hospital centers in Senegal Total RNAs from PBMCs of mild and cerebral malaria patients were profiled after hybridization with Agilent SurePrint G3 Human GE 8x60K Microarray to identify blood biomarkers for cerebral malaria phenotype Plasmodium falciparum malaria remains a major health problem in Africa. The mechanisms of pathogenesis leading to the severe form of the disease are not fully understood. Blood transcriptional profiles were investigated in patient with cerebral malaria, noncerebral malaria , and mild malaria by using the microarray technology. We identified a set of 447 genes that was differentially expressed between the three patient groups after a false discovery rate of 10%. Since the cerebral patients displayed a particular transcriptional pattern, we focused our analysis on the differences between cerebral malaria patients and mild malaria patients. We further found 849 genes differentially expressed after a false discovery rate of 10%. We validated our results by using the qPCR method for 5 genes. The enrichment analysis of their functional annotation indicates that genes involved in A, B, C pathways play a role in the occurrence of cerebral malaria. These results provide new insight into the potential effect of the dysregulation of gene expression and specific pathways. Host genetic variation may partly explain such alteration of gene expression. Further studies are required to investigate this in African populations.

2019-10-07 | GSE116306 | GEO

Gene expression profiling in blood from cerebral malaria patients and mild malaria patients living in Senegal.

Project description: Not available

| S-EPMC6821028 | biostudies-literature

Comparative genomic hybridization of Bordetella pertussis clinical isoltates circultating in Senegal

Project description:Genomic content of Bordetella pertussis clinical isolates circulating in Senegal

2009-01-08 | E-MEXP-1674 | biostudies-arrayexpress

Paired whole blood human transcription profiles from children with severe malaria and mild malaria

Project description:Whole blood transcriptomes from a longitudinal study of 5 Malawian children who first present with severe Plasmodium falciparum malaria, and return in one month with mild malaria We used microarrays to identify transcripts that were associated with each clinical presentation. A blood sample was taken upon presentation during the severe and mild malaria episodes in 5 Malawian children (total n=5 pairs) followed by RNA extraction and hybridization on Affymetrix GeneChip Human Gene 1.0 ST Array, using a paired analysis

2012-01-11 | E-GEOD-33811 | biostudies-arrayexpress

Paired whole blood human transcription profiles from children with severe malaria and mild malaria

2012-01-11 | GSE33811 | GEO

Plasmodium falciparum circumsporozoite protein study in Senegal

Project description:PfCSP in Senegal

| PRJEB39859 | ENA

Senegal Mangrove spcecies Raw data extract

Project description:senegal mangrove mangrove raw extract : ethanol and water

2023-11-22 | MSV000093463 | MassIVE

QTOF_UHPLC-MS/MS Senegal mangrove species

Project description:Mangrove senegal raw extract : Ethanol and water QTOF_UHPLC-MS/MS

2023-11-23 | MSV000093473 | MassIVE

Ehrlichia ruminantium strain:Senegal virulent

Project description:Ehrlichia ruminantium strain:Senegal virulent Genome sequencing and assembly

| PRJNA355590 | ENA

Expression data from whole blood samples of Rwandan adults with mild malaria with matched sample thirty days later (convalescence)

Project description:Host factors governing mild disease in adults who have developed clinical immunity to Plasmodium falciparum may provide insights for disease altering vaccine or interventions, to prevent severe malaria We used microarrays of whole blood samples during mild malaria and compared them in a paired analysis to whole blood microarray 30 days later. (n=19 pairs)

2014-12-19 | GSE64338 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data