Genomics

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Epigenetic analysis of CD8 T cells in absence of IL-10R signaling in murine tumor


ABSTRACT: Epigenetic analysis of CD8 T cells in absence of IL-10R signaling in murine tumor

PROVIDER: PRJNA478374 | ENA |

REPOSITORIES: ENA

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T cell exhaustion limits anti-tumor immunity and responses to immunotherapy. Here, we explored the microenvironmental signals regulating T cell exhaustion using a model of chronic lymphocytic leukemia (CLL). Single-cell analyses identified a subset of PD-1<sup>hi</sup>, functionally impaired CD8<sup>+</sup> T cells that accumulated in secondary lymphoid organs during disease progression and a functionally competent PD-1<sup>int</sup> subset. Frequencies of PD-1<sup>int</sup> TCF-1<sup>+</sup> CD  ...[more]

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