Genomics

Dataset Information

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Gestational diabetes adversely affects pancreatic islet development and function in the rat offspring


ABSTRACT: Gestational diabetes adversely affects pancreatic islet development and function in the rat offspring

PROVIDER: PRJNA479837 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR7473790_1.fastq.gz Fastqsanger.gz
SRR7473790_2.fastq.gz Fastqsanger.gz
SRR7473800_1.fastq.gz Fastqsanger.gz
SRR7473800_2.fastq.gz Fastqsanger.gz
SRR7473791_1.fastq.gz Fastqsanger.gz
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Publications


Fetal exposure to gestational diabetes mellitus (GDM) and poor postnatal diet are strong risk factors for type 2 diabetes development later in life, but the mechanisms connecting GDM exposure to offspring metabolic health remains unclear. In this study, we aimed to determine how GDM interacts with the postnatal diet to affect islet function in the offspring as well as characterize the gene expression changes in the islets. GDM was induced in female rats using a high-fat, high-sucrose (HFS) diet,  ...[more]

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