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Microarray expression data from iSOD2 adapted livers

ABSTRACT: Microarray expression data from iSOD2 adapted livers

PROVIDER: PRJNA479855 | ENA |

REPOSITORIES: ENA

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Microarray expression data from iSOD2 adapted livers

Project description:Transient mitochondrial stress can promote beneficial physiological responses and longevity, termed "mitohormesis." To interrogate mitohormetic pathways in mammals, we generated mice in which mitochondrial superoxide dismutase 2 (SOD2) can be knocked-down in an inducible and reversible manner (iSOD2-KD). Depleting SOD2 only during embryonic development did not cause post-natal lethality, allowing us to probe adaptive responses to mitochondrial oxidant stress in adult mice. Liver from adapted mice had increased mitochondrial biogenesis and antioxidant gene expression and fewer reactive oxygen species. Gene expression analysis implicated non- canonical activation of the Nrf2 antioxidant and PPAR-PGC-1 mitochondrial signaling pathways in this response. Transient SOD2 knock-down in embryonic fibroblasts from iSOD2-KD mice also resulted in adaptive mitochondrial changes, enhanced antioxidant capacity, and resistance to a subsequent oxidant challenge. We propose that mitohormesis in response to mitochondrial oxidative stress in mice involves sustained basal activation of mitochondrial and antioxidant signaling pathways to establish a heightened antioxidant state. We used microarrays to determine differentially expressed genes in mouse liver after transient SOD2 knock-down during mouse embryogenesis.

2018-07-06 | GSE116676 | GEO

Microarray measuring gene expression in livers of DO mice

Project description:Microarray measuring gene expression in livers of DO mice

| PRJNA388958 | ENA

miRNA expression data from neonatal and adult human livers

Project description:miRNA expression data from neonatal and adult human livers

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Expression data from livers of control and IlrunKO mice

Project description:Expression data from livers of control and IlrunKO mice

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Expression data of hepatocytes isolated from chimeric mouse livers repopulated with human hepatocytes and from normal human livers

Project description:We generated chimeric mice with livers that were predominantly repopulated with human hepatocytes. Hepatocytes were isolated from the chimeric mouse livers and their gene expressions were compared with hepatocytes isolated from normal human livers . Cluster and principal components analyses showed that gene expression profiles of hepatocytes from the chimeric mice and those from normal human livers were extremely closed. Additionally, we performed microarray experiments to examine gene expression in human tissues. This data was used for comparison with hepatocytes. A total of 22 tissues (bone marrow, cerebellum, colon, cortex, fetal brain, heart, kidney, liver, lung, pancreas, prostate, salivary gland, skeletal muscle, small intestine, spinal cord, spleen, stomach, testes, thymus, thyroid, trachea and uterus) were examined.

2012-11-27 | GSE33846 | GEO

Expression data of E7.5 primary germ layers [microarray]

Project description:Expression data of E7.5 primary germ layers [microarray]

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Expression data from livers of wild-type and HLJ1 knockout mice.

Project description:Expression data from livers of wild-type and HLJ1 knockout mice.

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Expression data from livers of rats with and without metformin treatment

Project description:Expression data from livers of rats with and without metformin treatment

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Expression data from livers of rats with and without phenformin treatment

Project description:Expression data from livers of rats with and without phenformin treatment

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Expression data from developing mouse livers

Project description:Roles of mesothelial cells (MCs) are poorly understood during liver development and injury. We identified podoplanin (Pdpn) as a cell surface markers for mesothelial cells in E12.5 mouse developing liver. To identify genes uniquely expressed in MCs, we isolated MCs from E12.5 mouse livers by FACS using anti-Pdpn antibodies and performed microarray analysis.

2013-02-04 | GSE39064 | GEO

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