Project description:To solve the problem of low FK520 production by Streptomyces hygroscopicus var. ascomyceticus FS35, PHB synthesis gene phaC and PHB decomposition gene fkbU were co-overexpressed in parent strain FS35 to construct recombinant strain OphaCfkbU. Surprisingly, recombinant strain OphaCfkbU accumulated more biomass than parent strain FS35 in whole fermentation. Therefore, to explore the effect of co-overexpression on the strain growth, comparative transcriptome analysis were carried out between parent strain FS35 and recombinant strain OphaCfkbU. Transcriptome data showed that co-overexpression increased the utilization of sugar sources and stimulated the generation of coenzymes, ribosome, acyl carrier proteins and sulfate donors. This study revealed the internal mechanism of the effect of PHB on strain growth, proving a reference for the role of PHB in other microorganisms.

2021-03-23 | GSE143832 | GEO

Peribacillus frigoritolerans strain:EB93

Project description:Peribacillus frigoritolerans strain:EB93 Genome sequencing and assembly

| PRJNA600051 | ENA

Peribacillus frigoritolerans strain:GD44

Project description:Peribacillus frigoritolerans strain:GD44 Genome sequencing and assembly

| PRJNA528841 | ENA

Peribacillus simplex strain:WY10

Project description:Peribacillus simplex strain:WY10 Genome sequencing and assembly

| PRJNA403971 | ENA

Peribacillus frigoritolerans strain:JHS1

Project description:Peribacillus frigoritolerans strain:JHS1 Genome sequencing and assembly

| PRJNA803000 | ENA

Peribacillus cavernae strain:L5

Project description:Peribacillus cavernae strain:L5 Genome sequencing and assembly

| PRJNA511554 | ENA

Peribacillus simplex strain:VanAntwerpen02

Project description:Peribacillus simplex strain:VanAntwerpen02 Genome sequencing and assembly

| PRJNA302546 | ENA

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