Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Sorted BCC timecourse after Vismo treatment - MCT, 6d, 14d

ABSTRACT: Sorted BCC timecourse after Vismo treatment - MCT, 6d, 14d

PROVIDER: PRJNA480703 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Sorted BCC timecourse after Vismo treatment - MCT, 6d, 14d

Project description:K14Cre-ER; Ptch1fl/fl; p53fl/fl;Lgr5GFP mice were aged until the appropriate tumor density was achieved. Skin samples were taken from control mice (untreated) or mice treated for 6 days or 14 days at twice a day dosing with vismodegib (75mg/kg body weight). RNA was extracted from freshly FACS sorted tumor cells based on GFP intensity. The "SAMPLE_ID" sample characteristic is a sample identifier internal to Genentech. The ID of this project in Genentech's ExpressionPlot database is PRJ0014328

2018-08-08 | GSE116961 | GEO

MCT-1 enhances translation

Project description:MCT-1 is an oncogene initially identified in a human T-cell lymphoma. Subsequently, MCT-1 protein levels were found to be elevated in a subset of diffuse large B-cell lymphoma. Forced expression of MCT-1 has recently been shown to induce cell proliferation as well as activate survival-related pathways protecting lymphoid cells from apoptosis. We document here that MCT-1 interacts with the density-regulated protein (DENR/DRP), containing the SUI1 translation initiation domain, found in many translation initiation factors. MCT-1 contains the PUA domain, a recently described RNA binding domain that is found in several tRNA and rRNA modification enzymes. Our findings established that MCT-1 protein is interacting with the cap complex through its PUA domain and enhances translation. Furtheremore, our data support a putative role for the MCT-1 oncogene in translation and suggests a mechanism for its role in lymphomagenesis. Keywords: Gene upregulation by MCT-1

2006-09-15 | GSE4805 | GEO

14d OV scRNA-seq

Project description:14d OV scRNA-seq

| PRJNA597329 | ENA

Expression data from mouse basal cell carcinoma (BCC) and normal epidermis, and BCC cell line treated with cyclopamine

Project description:Activation of the Sonic hedgehog (Shh) signaling pathway due to Patched 1 (PTCH1) mutation is a key event in sporadic and familial basal cell carcinoma (BCC) development. To find out the specific pathway for therapeutic intervention, we developed a mouse BCC model by skin specific Ptch1 inactivation, and sought to identify novel Shh targets. We used microarrays to identify up-regulated genes in mouse BCC. We used microarrays to identify down-regulated genes in mouse BCC cell line by cyclopamine.

2018-01-15 | GSE20065 | GEO

Streptococcus mutans 14D

Project description:Streptococcus mutans 14D genome sequencing project.

| PRJNA49837 | ENA

Murine BCC Cells: dio3 interfered vs control

Project description:MicroRNA expression profiling of mouse basal cell carcinoma (BCC) cells comparing BCC cells transfected with a stealth for dio3 transcript or control stealth-RNA.

2016-02-24 | GSE78265 | GEO

RNA sequencing of lung tissue from Angiotensin2/TRV023/losartan treated MCT rats

Project description:We report the application of RNA sequencing in lung tissues of MCT rats, that were treated with Angiotensin 2 or TRV023 or Losartan to study their effects on Pulmonary hypertension. We received FPKM data of each gene from each group of MCT rats. The gene expression of the study MCT rats were normalized to control MCT rat. The differentially expressed genes in Angiotensin 2 and TRV023 treated MCT rats, confirmed that like Angiotensin 2, TRV023 is also involved in vascular remodelling and lead to worsening of pulmonary hypertension.

2021-09-08 | GSE183339 | GEO

Murine BCC Cells: dio3 interfered vs control

Project description:MicroRNA expression profiling of mouse basal cell carcinoma (BCC) cells comparing BCC cells transfected with a stealth for dio3 transcript or control stealth-RNA. Two-condition experiment, Stealth-D3 vs Stealth-CTR cells. Biological replicates: 3 Stealth-D3 and 3 Stealth-CTR, independently grown and harvested. Single RNA were pooled. One replicate per array.

2016-02-24 | E-GEOD-78265 | biostudies-arrayexpress

Yersinia pestis strain:14D

Project description:Yersinia pestis strain:14D Genome sequencing

| PRJNA669044 | ENA

ATAC sequencing of sorted BCC cells after vismodegib treatment

Project description:ATAC sequencing of sorted BCC cells after vismodegib treatment

| PRJNA480705 | ENA