Genomics

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Effect of curaxin CBL0137 on expression of genes in MM1.S and HeLa S3 cells


ABSTRACT: Effect of curaxin CBL0137 on expression of genes in MM1.S and HeLa S3 cells

PROVIDER: PRJNA482641 | ENA |

REPOSITORIES: ENA

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Publications


Recently we characterized a class of anti-cancer agents (curaxins) that disturbs DNA/histone interactions within nucleosomes. Here, using a combination of genomic and in vitro approaches, we demonstrate that curaxins strongly affect spatial genome organization and compromise enhancer-promoter communication, which is necessary for the expression of several oncogenes, including MYC. We further show that curaxins selectively inhibit enhancer-regulated transcription of chromatinized templates in cel  ...[more]

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