Genomics

Dataset Information

0

The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity-independent genomic targeting


ABSTRACT: The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity-independent genomic targeting

PROVIDER: PRJNA483037 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity-independent genomic targeting.

Pan Joshua J   McKenzie Zachary M ZM   D'Avino Andrew R AR   Mashtalir Nazar N   Lareau Caleb A CA   St Pierre Roodolph R   Wang Lu L   Shilatifard Ali A   Kadoch Cigall C  

Nature genetics 20190311 4


Perturbations to mammalian switch/sucrose non-fermentable (mSWI/SNF) chromatin remodeling complexes have been widely implicated as driving events in cancer<sup>1</sup>. One such perturbation is the dual loss of the SMARCA4 and SMARCA2 ATPase subunits in small cell carcinoma of the ovary, hypercalcemic type (SCCOHT)<sup>2-5</sup>, SMARCA4-deficient thoracic sarcomas<sup>6</sup> and dedifferentiated endometrial carcinomas<sup>7</sup>. However, the consequences of dual ATPase subunit loss on mSWI/S  ...[more]

Similar Datasets

| S-EPMC6755913 | BioStudies
2019-03-11 | GSE117311 | GEO
2019-03-11 | GSE117301 | GEO
2019-03-11 | GSE117734 | GEO
| PRJNA481742 | ENA
| PRJNA483038 | ENA
| PRJNA481733 | ENA
| S-EPMC3587198 | BioStudies
2013-01-01 | S-EPMC3853085 | BioStudies
2019-03-11 | GSE117735 | GEO