Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Sequencing of human MRC-5 fibroblasts during replicative senescence (smallRNA)

ABSTRACT: Sequencing of human MRC-5 fibroblasts during replicative senescence (smallRNA)

PROVIDER: PRJNA483224 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Sequencing of human HFF fibroblasts during replicative senescence (smallRNA)

Project description:Sequencing of human HFF fibroblasts during replicative senescence (smallRNA)

| PRJNA483225 | ENA

Sequencing of human MRC-5 fibroblasts during replicative senescence (smallRNA)

Project description:Comparison of small RNA gene expression profiles of human fibroblasts at different population doublings. RNA-seq data comprise 5 groups: 32, 42, 52, 62 and 72 Pds. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE117818 | GEO

Transcription profiling of human mammary epithelial cells HMECs in replicative senescence vs fibroblasts

Project description:Telomere shortening in populations of human mammary epithelial cells (HMECs) that survive early replicative arrest (M0) by the inactivation of p16INK4A during cell culture on plastic dishes leads to a state of permanent replicative arrest termed senescence. While culture of HMECs on feeder layers abrogates M0 and p16INK4A inactivation, progressive telomere attrition in these cells also eventually results in permanent replicative arrest. Expression of telomerase prevents both senescence on plastic (S-P) and senescence on feeder layers (S-FL) in HMECs, as it does also in cultured primary human fibroblasts. We report here that the gene expression profiles of senescence in HMECs of the same lineage maintained under different culture conditions showed surprisingly little commonality. Moreover, neither of these senescence-associated profiles in HMECs resembles the profile for senescence in human fibroblasts. These results indicate that senescence-associated alterations in gene expression resulting from telomere attrition are affected by culture conditions as well as by cell origins, and argue that replicative senescence at the molecular level is a diverse rather than unique cellular process.

2005-11-01 | E-SMDB-2210 | biostudies-arrayexpress

Human primary fetal lung fibroblasts (HFL-1) undergoing replicative senescence

Project description:We profiled the global gene expression of human primary fetal lung fibroblasts (HFL-1) at different stages while they were undergoing replicative senescence

2020-08-10 | GSE144703 | GEO

Transcriptome analysis of IMR-90 human fibroblasts following oncogene-induced and replicative senescence

Project description:By transcriptome analysis of IMR-90 human fibroblasts following oncogene-induced senescence (OIS) and replicative senescence (RS), we identified commonly regulated genes in both conditions.

2017-03-30 | GSE86546 | GEO

Human primary fetal lung fibroblasts (HFL-1) undergoing replicative senescence

Project description:Human primary fetal lung fibroblasts (HFL-1) undergoing replicative senescence

| PRJNA604609 | ENA

Transcription profiling of human mammary epithelial cells HMECs (S-FL, S-P and PGA) during replicative senescence

2005-11-01 | E-SMDB-2046 | biostudies-arrayexpress

RNA-seq of young and quiescent (9 days) MRC-5 human fibroblasts

Project description:Comparison of gene expression profiles of quiescent MRC-5 fibroblasts and young MRC-5 fibroblasts. Jena Centre for Systems Biology of Ageing – JenAge (www.jenage.de)

2021-10-19 | GSE118693 | GEO

Sequencing of human HFF fibroblasts during replicative senescence (smallRNA)

Project description:small RNA gene expression profiles of senescent human fibroblasts were compared to young proliferating fibroblasts. RNA-seq data comprises 5 groups: 16, 26, 46, 64 and 74 population doublings of HFF fibroblasts. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE117817 | GEO

Analysis of the senescence transcriptome in TRF2dBdM-induced senescence and replicative senescence [microarray]

Project description:We stably infected IMR90 fibroblasts with lentiviral vectors expressing doxycycline-inducible TRF2dBdM or vector control. Cells were treated with 1mg/ml of doxycycline for 7 days to induce senescence in the cells expressing TRF2dBdM before collecting RNA. IMR90 cells, either young (passage 10, population doubling ~20) or old (passage 24, population doubling ~40-48) were also used as a model of replicative senescence. The transcriptomes were analyzed using RNA microarrays.

2021-02-12 | GSE153922 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data