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ARID3a Gene Profiles are Strongly Associated with Human Interferon Alpha Production

ABSTRACT: ARID3a Gene Profiles are Strongly Associated with Human Interferon Alpha Production

PROVIDER: PRJNA483394 | ENA |

REPOSITORIES: ENA

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ARID3a Gene Profiles are Strongly Associated with Human Interferon Alpha Production

Project description:Percentages of ARID3a-expressing low density neutrophils in SLE patients correlate with lupus disease activity and Type I IFN production. ARID3a protein levels also correlate with interferon expression in plasmacytoid dendritic cells. Gene profiles mechanistically link ARID3a with inflammatory pathway regulation.

2018-09-26 | GSE117836 | GEO

ARID3a gene profiles are strongly associated with human interferon alpha production.

Project description: Not available

| S-EPMC6497177 | biostudies-literature

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Project description:ARID3a Gene Profiles are Strongly Associated with Human Interferon Alpha Production

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Interferon-alpha signaling promotes AGM HSC maturation

Project description:Interferon-alpha promotes engraftment of mid-gestation hematopoietic stem cells by promoting competitiveness and restore the hematopoietic defect of Arid3a knockout embryos We used microarray to response of AGM HSCs (VE+CD45+) to IFNa (0.5ng/ml) treatment for 4 hours

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Whole blood transcriptome alteration between pigs with extreme in vivo dsRNA-induced serum interferon-alpha production

Project description:The interferon (IFN) is a major effector of the innate immunity which mediates an adaptive immune response against broad spectrum pathogens. The aim of this work has been to investigate the differences of the virus mimic dsRNA (Poly I:C)-inducted in vivo transcriptomic alteration between pigs with high (HIGH) and low (LOW) serum interferon-alpha production. The pigs with extreme yield of induced interferon-alpha from a F2 resource population were selected for whole blood gene expression analysis using the porcine Affymetrix microarray

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CMK LC-MS/MS after CoIP of ARID3A

Project description:In order to determine proteins interacting with ARID3A in the ML-DS cell line CMK, we performed CoIP of endogenous ARID3A followed by LC-MS/MS

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ARID3a is Required for Erythrocyte Lineage Differentiation of Hemin Stimulated Human K562 Cells

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Project description:Host cells produce interferon (IFN) in response to viral infections. Secreted interferon results in the transcription and production of hundreds of interferon-stimulated genes (ISGs). A genome-wide CRISPR screen using IFN alpha-treated Huh7.5 cells was performed to determine which ISGs were required in order for host cells to suppress yellow fever virus (YFV) infection.

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Arid3a is required for mammalian placenta development

Project description:Previous studies in the mouse indicated that Arid3a plays a critical role in the first cell fate decision required for generation of trophectoderm (TE). Here, we demonstrate that Arid3a is widely expressed during mouse and human placentation and essential for early embryonic viability. Arid3a is located within trophoblast giant cells and other trophoblast-derived cell subtypes in the junctional and labyrinth zones of the placenta. Conventional Arid3a knockout embryos suffer restricted intrauterine growth with sever defects in placental structural organization. Arid3a null placentas show aberrant expression of subtype-specific markers as well as significant alteration in inflammatory response-related genes, cytokines and chemokines. We provide evidence that BMP4-mediated induction of trophoblast stem (TS)-like cells from human induced pluripotent (iPS) stem cells results in ARID3A upregulation and cytoplasmic to nuclear translocation. Overexpression of ARID3A in human iPS and BMP4-mediated TS-like cells up-regulated TE markers, whereas pluripotent markers were down-regulated. Our results indicate that the roles of Arid3a are conserved and essential for mammalian placental development through regulation of both intrinsic and extrinsic developmental programs. Placentas of E10.5 and E11.5 wild type (WT) and Arid3a-/- mice were generated by deep sequencing, using Illumina

2016-07-01 | E-GEOD-79638 | biostudies-arrayexpress

Arid3a is required for mammalian placenta development

2016-07-01 | GSE79638 | GEO

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