Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single cell dissection of Chemical Reprogramming from Fibroblasts into functional Chondrocytes

ABSTRACT: Single cell dissection of Chemical Reprogramming from Fibroblasts into functional Chondrocytes

PROVIDER: PRJNA485015 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

High-Resolution Dissection of Chemical Reprogramming from Fibroblasts into Functional Articular Chondrocytes

Project description:High-Resolution Dissection of Chemical Reprogramming from Fibroblasts into Functional Articular Chondrocytes

| PRJNA484940 | ENA

Single cell dissection of Chemical Reprogramming from Fibroblasts into functional Chondrocytes

Project description:We used single cell analysis to systematically dissect the sequential changes of cellular phenotypes during fibroblast-chondrocyte direct reprograming.1401 single-cell transcriptomes were measured in total (232 MEFs of day0, 577 chemical-induced intermediate cells (ci-ICs) of day6, 311 ci-chons of day 34, 281 mouse primary chondrocytes (mchons) as positive control). We found that ci-chons and mchons shared similar subpopulation with specifically expression of cartilage-related markers. The findings also indicated that in the early induction, fibroblasts to lose their original features, and transit into a cartilage progenitor intermediate state.

2018-11-19 | GSE118234 | GEO

Chemical reprogramming of human fibroblasts

Project description:Chemical reprogramming of human fibroblasts

| PRJNA509474 | ENA

High-Resolution Dissection of Chemical Reprogramming from Fibroblasts into Functional Articular Chondrocytes

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-11-19 | GSE118236 | GEO

Chemical dissection of vtamin D activity

Project description:Chemical dissection of vtamin D activity

| PRJNA556890 | ENA

Chemical reprogramming of human fibroblasts

Project description:The compound (O4I3) showed a remarkable OCT4 induction, which at least in part, is due to the inhibition of H3K4-specific lysine demethylase (KDM5, also known as JARID1). Experiments demonstrated that KDM5A, serves as a reprogramming barrier via interference with the enrichment of H3K4Me3 at the OCT4 promoter. Thus, our results introduce a new class of KDM5 chemical inhibitors and provide further insight into the pluripotency-related properties of KDM5-family members.

2018-12-12 | GSE123668 | GEO

Chemical reprogramming of fibroblasts to photoreceptor like cells

Project description:Chemical reprogramming of fibroblasts to photoreceptor like cells

| PRJNA576241 | ENA

In vivo Chemical Reprogramming of Astrocytes into Functional Neurons

Project description:In mammals, many organs lack robust regenerative abilities. Lost cells in impaired tissue could potentially be compensated by converting nearby cells in situ through in vivo reprogramming. Small molecule-induced reprogramming offers a spatiotemporally flexible and non-integrative strategy for altering cell fate, which is, in principle, favorable for in vivo reprogramming in organs with notoriously poor regenerative abilities, such as the brain. Here, we demonstrate that in adult mouse brain, small molecules can reprogram astrocytes into functional neurons. The in situ chemically induced neurons resemble endogenous neurons in gene expression profiles, electrophysiological properties and synaptic connectivity. Our study demonstrates, for the first time, in vivo chemical reprogramming in the adult brain and provides a novel approach for developing neuronal replacement therapies.

2023-02-02 | GSE144993 | GEO

Chemical reprogramming of fibroblasts to photoreceptor like cells [RNA-Seq]

Project description:Chemical reprogramming of fibroblasts to photoreceptor like cells [RNA-Seq]

| PRJNA576236 | ENA

Chemical reprogramming of fibroblasts to photoreceptor like cells [ATAC-Seq]

Project description:Chemical reprogramming of fibroblasts to photoreceptor like cells [ATAC-Seq]

| PRJNA576238 | ENA