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Transcriptomic analysis of trametinib-resistant HCT116 colorectal carcinoma cells compared to the parental control cells

ABSTRACT: Transcriptomic analysis of trametinib-resistant HCT116 colorectal carcinoma cells compared to the parental control cells

PROVIDER: PRJNA485782 | ENA |

REPOSITORIES: ENA

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Transcriptomic analysis of trametinib-resistant HCT116 colorectal carcinoma cells compared to the parental control cells

Project description:HCT116 cells were treated with with increasing concentrations of trametinib over 2 months. Drug-resistant clones emerged and were cultured in the presence of 30 nmol/L trametinib. These cells exhibited a greater than 10-fold increase in the GI50 for trametinib compared to the parental cell line. RNA-seq of the resistant clone HCT116_R4 versus the parental cells identified differentially expressed genes potentially involved in resistance.

2018-10-23 | GSE118490 | GEO

Transcription profiling of human HCT116 parental cells treated with 5-FU or SN38 and non-treated parental cells, 5-FU resistant and SN39 resistant cells

Project description:The transcriptional profiles of the HCT116 parental cells following treatment with either 5-FU or SN38 for 24h were assessed. In addition, basal comparisons between HCT116 parental and HCT116 5-FU -resistant and HCT116 SN38-resistant cells were also assessed.

2009-03-30 | E-MEXP-1691 | biostudies-arrayexpress

Differential ncRNAs of oxaliplatin-resistant versus parental HCT116 cells

Project description:Oxaliplatin resistance frequently leads to therapeutic failure in colorectal cancer (CRC). Increasing evidence has shown that noncoding RNAs (ncRNAs) play pivotal roles in chemoresistance of CRC. However, the roles and mechanisms of ncRNAs in oxaliplatin resistance are not well understood. In this study, to identify the ncRNAs induced by oxaliplatin, we profile the expression of ncRNAs in oxaliplatin-resistant HCT116 CRC cells (HCT116oxR) and parental HCT116 cells using next-generation sequencing technology.

2023-08-31 | GSE119603 | GEO

Unirradiated HCT116-Clone2 cells

Project description:cDNA microarray study of unirradiated X-radiation (XR) resistant HCT116-Clone2 cells versus unirradiated HCT116-Clone10 cells. HCT116-Clone10 cells have similar XR response with parental HCT116 cells. Keywords: repeat sample

2004-06-04 | GSE798 | GEO

Unirradiated HCT116-CloneK cells

Project description:cDNA microarray study of unirradiated X-radiation (XR) sensitive HCT116-CloneK cells versus unirradiated HCT116-Clone10 cells. HCT116-Clone10 cells have similar XR response with parental HCT116 cells. Keywords = X-radiation (XR), XR sensitive, colorectal cancer cells, HCT1116 Keywords: repeat sample

2003-12-08 | GSE523 | GEO

Microarray gene expression analyses of HCT116 parental and isogenic p53KO cell lines

Project description:Untreated cells were used for analysis of the basal gene expression levels in HCT116 parental and isogenic p53KO cell lines grown to confluency to elucidate the genes/pathways that are differentially regulated and dependent on the p53 pathway.

2023-01-02 | GSE207647 | GEO

HCT116-Clone2 cells 10 min after XR treatment at 4 Gy

Project description:cDNA microarray study of X-radiation (XR) resistant HCT116-Clone2 cells 10 minutes after XR treatment at 4Gy versus unirradiated HCT116-Clone10 cells. HCT116-Clone10 cells have similar XR response with parental HCT116 cells. Keywords = X-radiation (XR) Keywords = XR resistant Keywords = colorectal cancer cells Keywords = HCT116 Keywords: repeat sample

2004-06-04 | GSE799 | GEO

HCT116-Clone2 cells 24 hours after XR treatment at 4 Gy

Project description:cDNA microarray study of X-radiation (XR) resistant HCT116-Clone2 cells 24 hours after XR treatment at 4Gy versus unirradiated HCT116-Clone10 cells. HCT116-Clone10 cells have similar XR response with parental HCT116 cells. Keywords = X-radiation (XR) Keywords = XR resistant Keywords = colorectal cancer cells Keywords = HCT116 Keywords: repeat sample

2004-06-04 | GSE801 | GEO

HCT116-Clone2 cells 6 hours after XR treatment at 4 Gy

Project description:cDNA microarray study of X-radiation (XR) resistant HCT116-Clone2 cells 6 hours after XR treatment at 4Gy versus unirradiated HCT116-Clone10 cells. HCT116-Clone10 cells have similar XR response with parental HCT116 cells. Keywords = X-radiation (XR) Keywords = XR resistant Keywords = colorectal cancer cells Keywords = HCT116 Keywords: repeat sample

2004-06-04 | GSE800 | GEO

HCT116-CloneK cells 24 hours after XR treatment at 4 Gy

Project description:cDNA microarray study of X-radiation (XR) sensitive HCT116-CloneK cells 24 hours after XR treatment at 4Gy versus unirradiated HCT116-Clone10 cells. HCT116-Clone10 cells have similar XR response with parental HCT116 cells. Keywords = X-radiation (XR), XR sensitive, colorectal cancer cells, HCT1116 Keywords: repeat sample

2003-12-08 | GSE526 | GEO

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