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Molecular specification of cell types underlying central and peripheral vision in primates

ABSTRACT: Molecular specification of cell types underlying central and peripheral vision in primates

PROVIDER: PRJNA485982 | ENA |

REPOSITORIES: ENA

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Molecular specification of cell types underlying central and peripheral vision in primates (macaque peripheral single cell RNA-seq)

Project description:Among mammals, only primates including human possess a small central retinal region called the fovea, which mediates high acuity vision. As other mammals lack a fovea, molecular bases of its specialized function and dysfunction in retinal diseases remain poorly understood. By analyzing >165,000 single-cell transcriptomes from macaque fovea and peripheral retina, we identified and molecularly characterized >60 major cell types in each region. A few cell types are unique to each region, and there are also substantial differences in proportions and gene expression between corresponding types in the two areas, some of which can be related to functional differences. Comparison of macaque and mouse retinal taxonomies reveals both similarities and differences between species. Many molecular features of macaque retinal cell types are conserved in two other primates, marmosets and humans, and key human retinal disease-associated genes are expressed in specific macaque cell types

2019-02-06 | GSE118852 | GEO

Molecular specification of cell types underlying central and peripheral vision in primates (macaque fovea single cell RNA-seq)

2019-02-06 | GSE118546 | GEO

Molecular specification of cell types underlying central and peripheral vision in primates (macaque fovea single cell RNA-seq)

Project description:Molecular specification of cell types underlying central and peripheral vision in primates (macaque fovea single cell RNA-seq)

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Molecular specification of cell types underlying central and peripheral vision in primates (macaque peripheral single cell RNA-seq)

Project description:Molecular specification of cell types underlying central and peripheral vision in primates (macaque peripheral single cell RNA-seq)

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Molecular specification of cell types underlying central and peripheral vision in primates

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-02-06 | GSE118480 | GEO

Vision-dependent specification of cell types and function in the developing cortex

Project description:The role of postnatal experience in sculpting cortical circuitry, while long appreciated, is poorly understood at the level of cell types. We explore this in the mouse primary visual cortex (V1) using single-nucleus RNA-sequencing, visual deprivation, genetics, and functional imaging. We find that vision selectively drives the specification of glutamatergic cell types in upper layers (L) (L2/3/4), while deeper-layer glutamatergic, GABAergic, and non-neuronal cell types are established prior to eye opening. L2/3 cell types form an experience-dependent spatial continuum defined by the graded expression of ~200 genes, including regulators of cell adhesion and synapse formation. One of these, Igsf9b, a vision-dependent gene encoding an inhibitory synaptic cell adhesion molecule, is required for the normal development of binocular responses in L2/3. In summary, vision preferentially regulates the development of upper-layer glutamatergic cell types through the regulation of cell type-specific gene expression programs.

2021-12-27 | GSE190940 | GEO

Vision-dependent specification of cell types and function in the developing cortex

Project description:Vision-dependent specification of cell types and function in the developing cortex

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Project description:Molecular specification of cell types underlying central and peripheral vision in primates

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Project description:Primates

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Genetic and transcriptomic identification of sensory neuron types underlying chronic pain in primates

Project description:Molecular characterization of the individual neuron types existing in the primate dorsal root ganglion and the relation to model organisms used for studying somatosensation and pain is critical for understanding the cellular origin of chronic pain and for translational aspects of biomedical research. However, molecular insights into the primate dorsal root ganglion are missing and a systematic comparison of strategies for somatosensation between the mouse and primates is lacking. Here we classify non-human primate sensory neurons based on their transcriptome and identify neuronal types with heritability to chronic pain. We identify nine neuronal types and use machine learning to expose an overall cross-species conserved strategy and shared taxonomy for nociception, although with differences at individual gene level, highlighting the importance of incorporating primate knowledge for the successful translation of discoveries in rodent model organisms. Genomic loci implicated in chronic pain were mapped onto specific primate sensory neuron types to identify the cellular origin of chronic pain. The common-variant genome-wide association results for chronic pain point to the same cells at the same pain sites and concentrate on two different neuronal types between pain disorders, suggesting that causative cell types and molecular mechanisms are different between different pain conditions.

2021-03-11 | GSE148238 | GEO

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