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Hormesis underlies the adaptive response in methylmalonic acidemia (MMA)

ABSTRACT: Hormesis underlies the adaptive response in methylmalonic acidemia (MMA)

PROVIDER: PRJNA487064 | ENA |

REPOSITORIES: ENA

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Hormesis underlies the adaptive response in methylmalonic acidemia (MMA)

Project description:Methylmalonic acidemia (MMA), an organic acidemia characterized by metabolic instability and multiorgan complications, is most frequently caused by mutations in methylmalonyl-CoA mutase (MUT). To define the metabolic adaptations in MMA, in the chronic and acute settings, we studied a mouse model generated by transgenic expression of Mut in the muscle. Mut-/-;TgINS-MCK-Mut mice accurately replicate the hepato-renal mitochondriopathy and growth failure seen in severely affected patients, and were used to characterize the response to fasting. The hepatic transcriptome in MMA mice was characterized by the chronic activation of stress-related pathways and responded abberrantly to fasting when compared to controls.

2019-08-01 | GSE118862 | GEO

Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy [ATAC-Seq]

Project description:This study examines the reorganization of transcriptionally active chromatin that underlies the adaptive response of glioblastoma cells to radiotherapy.

2023-12-01 | GSE211148 | GEO

Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy [ChIP-Seq]

Project description:This study examines the reorganization of transcriptionally active chromatin that underlies the adaptive response of glioblastoma cells to radiotherapy.

2023-12-01 | GSE211147 | GEO

Adaptive immune response that restrains ALV

Project description:Adaptive immune response that restrains ALV

| PRJNA824028 | ENA

Quantitative Tyr Phosphoproteomic Analyses of Tumor Adaptive Response to MAPK Inhibition

Project description:Although targeted inhibition of the MAPK pathway has achieved remarkable patient responses in many cancers with MAPK hyperactivation, the development of resistance has remained a critical challenge. Besides genomic resistance mechanisms, adaptive tumor response also underlies the resistance to targeted MAPK inhibitors. It is being increasingly appreciated that such bypass mechanisms often lead to the activation of many pro-survival kinases, which complicates the rational design of combination therapies. Here we performed global tyrosine phosphoproteomic (pTyr) analyses and demonstrated that targeted inhibition of MAPK signaling in melanoma cells leads to a profound remodeling of the pTyr proteome. Intriguingly, many of these kinases contain a cholesterol binding motif, suggesting that altered cholesterol metabolism might drive, in a coordinated fashion, the activation of these kinases. Indeed, we found a dramatic accumulation of intracellular cholesterol in melanoma cells (with BRAFV600E mutations) and non-small cell lung cancer cells (with KRasG12C mutations) treated with MAPK and KrasG12C inhibitors, respectively. Importantly, depletion of cholesterol not only prevents the MAPK inhibition-induced feedback activation of pTyr singling but also enhances the cytotoxic effects of MAPK inhibitors, both in vitro and in vivo. Taken together, our findings provide the evidence suggesting that cholesterol functions as a master regulator of the tumor adaptive response to targeted MAPK inhibitors. These results also suggest that MAPK inhibitors could be combined with cholesterol-lowering agents to achieve a more complete and durable response in tumors with hyperactive MAPK signaling.

2021-05-11 | PXD021877 | Pride

Abiotic stress response and adaptive phenology in fruit trees

Project description:Abiotic stress response and adaptive phenology in fruit trees

| PRJNA577143 | ENA

miR-106b-5p is a key player in adaptive response to drug-induced liver injury and liver regeneration by targeting vimentin

Project description:The key exosomal miRNAs in adaptive response to drug-induced liver (DILI) and liver regeneration were investigated and proved. This study aimed to decipher the mechanism of restorative events in the adaptive response to DILI by investigating circulating exosomal miRNAs. Using toosendanin-induced liver injury model, exosomal miR-106b-5p was identified as a robust driver in the adaptive response of TILI.

2020-11-07 | GSE160961 | GEO

Transcription factor IRF8 orchestrates the adaptive natural killer cell response

Project description:Transcription factor IRF8 orchestrates the adaptive natural killer cell response

| PRJNA449549 | ENA

Dynamic IFNβ signalling underlies treatment response to immune checkpoint therapy in cancer

Project description:Dynamic IFNβ signalling underlies treatment response to immune checkpoint therapy in cancer

| PRJNA644586 | ENA

Molecular Mechanisms of Early Response in Adaptive Cerebral Arteriogenesis

Project description:This study aims at a comprehensive understanding of the genomic program activated during early-phase of collateral vessel growth in a rat model for cerebral adaptive arteriogenesis (3-VO). While arteriogenesis constitutes a promising therapeutic concept for cerebrovascular ischemia, genomic profiles essential for therapeutic target identification were analysed solely for collateral arteries of the heart and periphery. Despite challenging anatomical conditions of the brain the 3-VO model allows identification of differentially expressed genes during adaptive cerebral arteriogenesis by selective removal of the posterior cerebral artery (PCA). Keywords: early response time course, selective collateral growth, brain

2008-09-01 | GSE6189 | GEO

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