Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Neuronal Methylome in Multiple Sclerosis

ABSTRACT: Neuronal Methylome in Multiple Sclerosis

PROVIDER: PRJNA489474 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Neuronal Methylome in Multiple Sclerosis

Project description:DNA methylation profiling of NeuN+sorted neuronal nuclei from post-mortem brain tissue of Multiple Sclerosis (MS) patients (n=10) (MS) and non-neurological controls (n=7) (non-MS). Genomic DNA was subjected to conventional BS-treatment as well as oxidative BS (oxBS)-conversion using TrueMethylTM 96 kit of CEGXTM (Cambridge Epigenetix Limited) to allow for subsequent detection of hydroxymethylation (5hmC = BS - oxBS).

2019-06-21 | GSE119532 | GEO

Multiple sclerosis and EAE

Project description:Multiple sclerosis and EAE

| PRJNA391342 | ENA

Methylome signature of bronchoalveolar cells from Multiple Sclerosis patients in relation to smoking

Project description:Methylome signature of bronchoalveolar cells from Multiple Sclerosis patients in relation to smoking

| PRJNA634374 | ENA

International Multiple Sclerosis Genomics Consortium (IMSGC) Genome Wide Association Study of Multiple Sclerosis

Project description:International Multiple Sclerosis Genomics Consortium (IMSGC) Genome Wide Association Study of Multiple Sclerosis

| PRJNA75425 | ENA

Transcription signature of Multiple Sclerosis

Project description:This SuperSeries is composed of the following subset Series: GSE17393: Transcription signature of Multiple Sclerosis in peripheral blood mononuclear cells. GSE17409: Pregnancy changes expression in peripheral blood mononuclear cells of healthy donors GSE17410: Pregnancy changes expression in peripheral blood mononuclear cells of Multiple Sclerosis (MS) patients Refer to individual Series

2010-01-10 | E-GEOD-17449 | biostudies-arrayexpress

Differential DNA methylation in Multiple Sclerosis

Project description:Differential DNA methylation in Multiple Sclerosis

| PRJNA417506 | ENA

Altered oligodendrocyte heterogeneity in Multiple sclerosis.

Project description:Altered oligodendrocyte heterogeneity in Multiple sclerosis.

| PRJNA484965 | ENA

Gene expression profiling of multiple sclerosis brain samples

Project description:Recent studies of cortical pathology in secondary progressive multiple sclerosis have shown that a more severe clinical course and the presence of extended subpial grey matter lesions with significant neuronal/glial loss and microglial activation are associated with meningeal inflammation, including the presence of lymphoid-like structures in the subarachnoid space in a proportion of cases. To investigate the molecular consequences of pro-inflammatory and cytotoxic molecules diffusing from the meninges into the underlying grey matter, we carried out gene expression profiling analysis of the motor cortex from 20 post-mortem multiple sclerosis brains with and without substantial meningeal inflammation and 10 non-neurological controls. Gene expression profiling of grey matter lesions and normal appearing grey matter not only confirmed the substantial pathological cell changes, which were greatest in multiple sclerosis cases with increased meningeal inflammation, but also demonstrated the upregulation of multiple genes/pathways associated with the inflammatory response. In particular, genes involved in tumour necrosis factor (TNF) signalling were significantly deregulated in MS cases compared to controls.

2019-12-17 | GSE135511 | GEO

gut microbes of multiple sclerosis

Project description:gut microbes of multiple sclerosis Raw sequence reads

| PRJNA480924 | ENA

A Case-Controlled Study for genotype-Phenotype Associations in Multiple Sclerosis (Genetic Multiple Sclerosis - GeneMSA)

Project description:A Case-Controlled Study for genotype-Phenotype Associations in Multiple Sclerosis (Genetic Multiple Sclerosis - GeneMSA)

| PRJNA75473 | ENA