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Screening regulated pathway and genes expression in polyI:C treated cerulein-induced AP mice models

ABSTRACT: Screening regulated pathway and genes expression in polyI:C treated cerulein-induced AP mice models

PROVIDER: PRJNA490448 | ENA |

REPOSITORIES: ENA

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Screening regulated pathway and genes expression in polyI:C treated cerulein-induced AP mice models

Project description:Pancreas tissue derived from mice with intraperitoneal injection of saline, cerulein or polyI:C plus cerulein, total RNA was extracted and deep sequenced to compare the gene expression profiles among control, acute pancreatitis and intervention of polyI:C on acute pancreatitis.

2019-05-15 | GSE119844 | GEO

High-Content Screening Identifies A Small Molecule That Restores AP-4-dependent Protein Trafficking In Neuronal Models Of AP-4-Associated Hereditary Spastic Paraplegia

Project description:Unbiased phenotypic screens in patient-relevant disease models offer the potential to detect therapeutic targets for rare diseases. In this study, we developed a high-throughput screening assay to identify molecules that correct aberrant protein trafficking in adaptor protein complex 4 (AP-4) deficiency, a rare but prototypical form of childhood-onset hereditary spastic paraplegia, characterized by mislocalization of the autophagy protein ATG9A. Using high-content microscopy and an automated image analysis pipeline, we screened a diversity library of 28,864 small molecules and identified a lead compound, BCH-HSP-C01, that restored ATG9A pathology in multiple disease models, including patient-derived fibroblasts and induced pluripotent stem cell-derived neurons. We used multiparametric orthogonal strategies and integrated transcriptomic and proteomic approaches to delineate potential mechanisms of action of BCH-HSP-C01. Our results define molecular regulators of intracellular ATG9A trafficking and characterize a lead compound for the treatment of AP-4 deficiency, providing important proof-of-concept data for future studies.

2024-01-26 | PXD042950 | Pride

Gene expression changes in the conceptus following maternal exposure to PolyI:C

Project description:We report the global transcript changes in the rat conceptus following maternal exposure to PolyI:C

2020-05-28 | GSE145167 | GEO

Screening RIPK3 dependent signaling pathway and genes expression in intestinal GVHD mice models

Project description:Screening RIPK3 dependent signaling pathway and genes expression in intestinal GVHD mice models

| PRJNA695374 | ENA

Expression data from monocyte-derived macrophages after stimulation with mock, LPS, PolyI:C and P3C.

Project description:Pre-stimulation of MDMs with LPS (signals via MyD88 and TRIF dependent pathways) and PolyI:C (signals via a TRIF dependent pathway) leads to a reduced viral infection. In contrast, pre-stimulation with P3C (signals via MyD88 dependent pathway) does not lead to a reduced viral infection. This microarray was performed to find genes that are specifically upregulated in LPS and PolyI:C stimulated MDMs but not P3C stimulated MDMs. So to give us leads into the mechanism involved in the reduction of viral infection. MDMs of four different donors were stimulated for 4h with mock, LPS, PolyI:C or P3C. RNA was isolated and gene expression of these cells was assessed. Gene expression of LPS, PolyI:C and P3C stimulated MDMs was compared to mock.

2013-07-01 | E-GEOD-41295 | biostudies-arrayexpress

Murine primary dendritic cells: Control vs. Influenza-infected vs. polyI:C stimulated.

Project description:MIcroRNA expression profiling of primary murine splenic dendritic cells (Flt3L expanded) comparing untreated cells to cells infected with Influenza A or stimulated with polyI:C in vitro. Three-condition experiment, Influenza A/PR/8/34 virus MOI=10 vs polyI:C 30 ug/mL vs. mock treated; RNA collected after 8 hours. 3 Independent biological replicates from cells prepared on different days. One replicate per array.

2012-12-05 | E-GEOD-36316 | biostudies-arrayexpress

PolyI:C stimulation of KO vs. WT BMDMs

Project description:Primary murine bone marrow derived macrophages (BMDMs) of Setdb2GT/GT and WT mice were stimulated with polyI:C and harvested at 0, 2 and 8h. Everything with biological triplicates (=cells from 3 individual mice per condition)

2014-11-23 | E-MTAB-2263 | biostudies-arrayexpress

Murine primary dendritic cells: Control vs. Influenza-infected vs. polyI:C stimulated.

2012-12-05 | GSE36316 | GEO

3-AP and Gemcitabine in Treating Patients With Advanced Solid Tumors or Lymphoma

Project description:This phase I trial is studying the best dose of 3-AP and the side effects of giving 3-AP together with gemcitabine in treating patients with advanced solid tumors or lymphoma. Drugs used in chemotherapy, such as 3-AP and gemcitabine (GEM), work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. 3-AP may help gemcitabine kill more cancer cells by making the cells more sensitive to the drug. 3-AP may also stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

| 2026481 | ecrin-mdr-crc

Expression data from monocyte-derived macrophages after stimulation with mock, LPS, PolyI:C and P3C.

2013-07-01 | GSE41295 | GEO

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