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Transcriptome profiling of wildtype, nonoperated mouse hearts compared to wildtype, sham operated hearts

ABSTRACT: Transcriptome profiling of wildtype, nonoperated mouse hearts compared to wildtype, sham operated hearts

PROVIDER: PRJNA494802 | ENA |

REPOSITORIES: ENA

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Transcriptome profiling of wildtype, nonoperated mouse hearts compared to wildtype, sham operated hearts

Project description:The purpose of the present study was to investigate the activation of the cardiac inflammatory response in the hearts of SHAM (surgical opening of the chest) mice in comparison to CONTROL hearts isolated from naïve (not operated) mice. Male C57BL/6J (10 weeks) were subjected to an open-chest ischemia-reperfusion (I/R) SHAM procedure in order to examine the effects of this surgery alone in producing cardiac inflammation. The procedure consisted of thoracotomy and a suture passed around the left anterior descending artery (LAD). The mouse chest was kept open for approximately 45 min. We chose to study an open-chest I/R SHAM because this is the reference surgery for the most common surgical procedure used to study cardiac inflammation. Mice were sacrificed 5 days after the procedure and the hearts were removed and used in RNAseq experiments.

2020-10-04 | GSE120867 | GEO

CPB vs sham-operated controls (1.2)

Project description:hearts from rats exposed to cardiopulmonary bypass (CPB) vs sham-operated controls Keywords = rat Keywords = heart Keywords = cytokine Keywords = inflammation Keywords: repeat sample

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Expression data from uninephrectomized dogs compared to sham operated dogs

Project description:Renal insufficiency is a risk factor for development of cardiovascular disease. In this study our aim was to investigate functional and structural changes in the heart of dogs with mild renal insufficiency induced by uninephrectomy (UNX). In addition to comprehensively assessing functional parameters 12 week after UNX or sham surgery, we harvested tissue for assessment of structural changes. Microarray analyses were performed on snap frosen tissue from the left atrium (LA) and left ventricle (LV) of UNX and sham operated animals. Gene expression in LA was compared between the groups, and gene expression in the LV was compared between the groups. We aimed to assess whether a potentially altered gene expression in the heart of the UNX group also included genes associated with cardiac remodeling. Six dogs were assigned to unineprectomy and 6 dogs were assigned to sham operation. Microarray analyses were performed on 5 samples from the left atrium of uninephrectomized animals and on 5 samples from the left atrium of sham operated animals. Further, microarray analyses were performed on 5 samples from the left ventricle of uninephcretomized animals and on 5 samples from the left ventricle of sham operated animals. No replicates were perfomed.

2013-06-13 | E-GEOD-47876 | biostudies-arrayexpress

Expression data from uninephrectomized dogs compared to sham operated dogs

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Cardiopulmonary bypass (CPB) vs sham-operated controls

Project description:heart from rats exposed to cardiopulmonary bypass (CPB) vs sham-operated controls Keywords: other

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Cardiopulmonary bypass (CPB) vs sham-operated controls

Project description:heart from rats exposed to cardiopulmonary bypass (CPB) vs sham-operated controls

2010-05-27 | E-GEOD-924 | biostudies-arrayexpress

Transcription profiling of left cardiac ventricle from rats with Aortic valve Regurgitation or sham operated rats

Project description:Compared Gene Expression Profiling of Rats with Aortic valve Regurgitation (AR) vs Sham operated Rats

2009-06-10 | E-TABM-490 | biostudies-arrayexpress

Expression data from MCAO or Sham operated rat blood [miRNA]

Project description:In the search for stroke biomarkers, miRNAs are gaining attention. To investigate novel miRNAs that work as stroke biomarkers, we used Middle Cerebral Artery Occlusion model of rats. By using microarray analysis and comparing with Sham operated rats, we extracted the miRNAs whose expressions are alterated by stroke.

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Expression data from MCAO or Sham operated rat blood [mRNA]

Project description:To analyze the gene expression alteration after stroke, we used Middle Cerebral Artery Occlusion model of rats. By comparing with Sham operated rats, we extracted the mRNAs whose expressions are alterated by stroke. Using microarray analysis, we aimed to grasp the overall expression alteration of mRNA in blood after stroke.

2018-02-14 | GSE97533 | GEO

Expression data from MCAO or Sham operated rat brain [mRNA]

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