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Effects of light-at-night on the rat liver - a role for the autonomic nervous system (Experiment 1)

ABSTRACT: Effects of light-at-night on the rat liver - a role for the autonomic nervous system (Experiment 1)

PROVIDER: PRJNA495167 | ENA |

REPOSITORIES: ENA

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Effects of light-at-night on the rat liver - a role for the autonomic nervous system (Experiment 1)

Project description:Exposure to light at night (LAN) has been associated with serious pathologies, including obesity, diabetes and cancer. Recently we showed that 2 hours of LAN impaired glucose tolerance in rats. Several studies have suggested that the autonomic nervous system (ANS) plays an important role in communicating these acute effects of LAN to the periphery. Here, we investigated the acute effects of LAN on the liver transcriptome of male Wistar rats. Expression levels of individual genes were not markedly affected by LAN, nevertheless pathway analysis revealed clustered changes in a number of endocrine pathways. Subsequently, we used selective hepatic denervations (sympathetic (Sx), parasympathetic (Px), total (Tx, i.e., Sx plus Px), sham) to investigate the involvement of the ANS in the effects observed. Surgical removal of the sympathetic or parasympathetic hepatic branches of the ANS resulted in many, but small changes in the liver transcriptome, including a pathway involved with circadian clock regulation, but it clearly separated the four denervation groups. On the other hand, analysis of the liver metabolome was not able to separate the denervation groups, and only 6 out of 78 metabolites were significantly up- or downregulated after denervations. Finally, removal of the sympathetic and parasympathetic hepatic nerves combined with LAN exposure clearly modulated the effects of LAN on the liver transcriptome, but left most endocrine pathways unaffected. Conclusion: One-hour light-at-night acutely affects the liver transcriptome. Part of this effect is mediated via the nervous innervation, as a hepatectomy modulated and reduced the effect of LAN on liver transcripts.

2018-10-10 | GSE120979 | GEO

Effects of light-at-night on the rat liver - a role for the autonomic nervous system (Experiment 2)

2018-10-10 | GSE120978 | GEO

Effects of light-at-night on the rat liver - a role for the autonomic nervous system (Experiment 2)

Project description:Effects of light-at-night on the rat liver - a role for the autonomic nervous system (Experiment 2)

| PRJNA495165 | ENA

Effects of light-at-night on the rat liver - a role for the autonomic nervous system

Project description:Effects of light-at-night on the rat liver - a role for the autonomic nervous system

| PRJNA495160 | ENA

Expression data from rat regenerating livers after autonomic nervous system is disrupted

Project description:Autonomic nervous system is widely distributed in liver, and some reserchers have found that disruppted autonomic nerves will delay liver regeneration. We used microarrays to further highlight the regulatory role of autonomic nervous system in liver regeneration at gene transcription level. Surgical operations of rat partial hepatectomy (PH) and its operation control (OC), sympathectomy combining partial hepatectomy (SPH), vagotomy combining partial hepatectomy (VPH), and total liver denervation combining partial hepatectomy (TDPH) were performed, and the expression profiles of regenerating liver at 2h were detected using Rat Genome 230 2.0 array. Then the significantly changed genes related to liver regeneration (LR)-, injury-, splanchnic nerve-LR-, vagal nerve-LR-, and autonomic nerve-LR-related genes were identified, respectively. The relevance of gene expression profiles and biological processes was analyzed by bioinformatics and systems biology.

2010-12-18 | E-GEOD-26138 | biostudies-arrayexpress

Expression data from rat regenerating livers after autonomic nervous system is disrupted

2010-12-18 | GSE26138 | GEO

Effects of light-at-night on the rat liver - a role for the autonomic nervous system

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-10-10 | GSE120980 | GEO

Effects of Light-at-Night on the Rat Liver - A Role for the Autonomic Nervous System.

Project description: Not available

| S-EPMC6596368 | biostudies-literature

Light at Night Exposure Effects on Differentiation and Cell Cycle in the Rat Liver With Autonomic Nervous System Denervation.

Project description: Not available

| S-EPMC6983860 | biostudies-literature