Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of chromatin accessibility due to loss of PIN1

ABSTRACT: Effect of chromatin accessibility due to loss of PIN1

PROVIDER: PRJNA495629 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Effect of chromatin accessibility due to loss of PIN1

Project description:The goal of this study was to determine the chromatin accessibility difference between WT and PIN1 knockout mouse embryonic fibroblasts.

2018-11-20 | GSE121094 | GEO

Effect of global MYC DNA binding due to loss of PIN1

Project description:Effect of global MYC DNA binding due to loss of PIN1

| PRJNA430961 | ENA

Effect of global MYC DNA binding due to loss of PIN1

Project description:The goal of this study was to determine the MYC binding difference between WT and PIN1 knockout mouse embryonic fibroblasts.

2018-11-20 | GSE109458 | GEO

Transcriptional changes of serum stimulation in mouse embryonic fibroblasts due to loss of PIN1

Project description:Transcriptional changes of serum stimulation in mouse embryonic fibroblasts due to loss of PIN1

| PRJNA430962 | ENA

Transcriptional changes of serum stimulation in mouse embryonic fibroblasts due to loss of PIN1

Project description:The goal of this study was to determine the transcriptional difference between WT and PIN1 knockout mouse embryonic fibroblasts.

2018-11-20 | GSE109457 | GEO

Pin1 mediates Ab42-mediated dendritic spine loss

Project description:Early-stage Alzheimer's disease is characterized by the loss of dendritic spines in the neocortex of the brain. This phenomenon precedes tau pathology, plaque formation, and neurodegeneration and likely contributes to synaptic loss, memory impairment, and behavioral changes in patients. Studies suggest that spine loss is induced by soluble, multimeric Ab42, whose post-synaptic signaling activates the protein phosphatase calcineurin. We investigated how calcineurin causes spine pathology and found that the cis-trans prolyl isomerase Pin1 is a critical downstream target of Ab42/calcineurin signaling. In spines, Pin1 interacts with and is dephosphorylated by calcineurin, which rapidly suppresses its isomerase activity. Pin1 knockout or Ab42 exposure induced mature spine loss in Ab42-treated wild-type cells but had no effect on Pin1 null neurons. The data implicate Pin1 in spine maintenance and synaptic loss in early Alzheimer's disease.

2018-02-14 | MSV000082066 | MassIVE

Expression data from Pin1 inhibitor ATRA and Pin1 knockdown

Project description:ATRA was identified as a Pin1 inhibitor via fluorescence polarization-based high throughput screening. We performed microarray expression profiling to demonstrate the similarity between ATRA and Pin1 KD at the genome-wide level APL NB4 cells in response to ATRRA or inducible Pin1 knockdown for 3 days were collected for RNA extraction and hybridization on Affymetrix microarrays. We sought to validate in genome-wide level whether similarity occurred between ATRA and Pin1 knockdown-treated NB4 cells.

2015-04-12 | E-GEOD-63059 | biostudies-arrayexpress

Effect of depletion of PIN1 on gene expression of breast cancer cells

Project description:To investigate the role of PIN1 in the regulation of immune response, we established PIN1 knouckout cell lines

2024-03-08 | GSE232285 | GEO

Expression data from Pin1 inhibitor ATRA and Pin1 knockdown

2015-04-12 | GSE63059 | GEO

Pin1/mutant-p53 jointly controlled genes

Project description:To investigate the specific gene expression program by which mutant-p53 and Pin1 control invasion and metastasis in breast cancer cells, we compared the transcriptomic profile of control, mutant-p53 depleted or Pin1 depleted MDA-MB-231 cells.

2011-05-30 | GSE26262 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data