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Quantifying post-transcriptional regulation in the development of Drosophila melanogaster [s2r]

ABSTRACT: Quantifying post-transcriptional regulation in the development of Drosophila melanogaster [s2r]

PROVIDER: PRJNA495911 | ENA |

REPOSITORIES: ENA

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Quantifying post-transcriptional regulation in the development of Drosophila melanogaster

Project description:Quantifying post-transcriptional regulation in the development of Drosophila melanogaster

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Quantifying post-transcriptional regulation in the development of Drosophila melanogaster [s2r]

Project description:Proteome and transcriptome often show poor correlation, hindering the system-wide analysis of post-transcriptional regulation. Here, the authors study proteome and transcriptome dynamics during Drosophila embryogenesis and present basic mathematical models describing the temporal regulation of most protein-RNA pairs.

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High-throughput sequencing of Drosophila melanogaster small RNAs from S2R+ cells

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Quantifying post-transcriptional regulation in the development of Drosophila melanogaster

Project description:Even though proteins are produced from mRNA, the correlation between mRNA levels and protein abundances is moderate in most studies, occasionally attributed to complex post-transcriptional regulation. To address this, we generated a paired transcriptome/proteome time course dataset with 14 time points during Drosophila embryogenesis. Despite a limited mRNA-protein correlation (ρ = 0.54), mathematical models describing protein translation and degradation explain 84% of protein time-courses based on the measured mRNA dynamics without assuming complex post-transcriptional regulation, and allow for classification of most proteins into four distinct regulatory scenarios. By performing an in-depth characterization of the putatively post-transcriptionally regulated genes, we postulated that the RNA-binding protein Hrb98DE is involved in post-transcriptional control of sugar metabolism in early embryogenesis and partially validated this hypothesis using Hrb98DE knockdown. In summary, we present a systems biology framework for the identification of post-transcriptional gene regulation for large-scale time-resolved transcriptome and proteome data.

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Quantifying post-transcriptional regulation in the development of Drosophila melanogaster.

Project description: Not available

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Drosophila melanogaster strain:S2R+ cell lines

Project description:Drosophila melanogaster strain:S2R+ cell lines Raw sequence reads

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