Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Quantifying post-transcriptional regulation in the development of Drosophila melanogaster

ABSTRACT: Quantifying post-transcriptional regulation in the development of Drosophila melanogaster

PROVIDER: PRJNA495916 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Quantifying post-transcriptional regulation in the development of Drosophila melanogaster [devel]

Project description:Quantifying post-transcriptional regulation in the development of Drosophila melanogaster [devel]

| PRJNA495910 | ENA

Quantifying post-transcriptional regulation in the development of Drosophila melanogaster [s2r]

Project description:Quantifying post-transcriptional regulation in the development of Drosophila melanogaster [s2r]

| PRJNA495911 | ENA

Quantifying post-transcriptional regulation in the development of Drosophila melanogaster

Project description:Even though proteins are produced from mRNA, the correlation between mRNA levels and protein abundances is moderate in most studies, occasionally attributed to complex post-transcriptional regulation. To address this, we generated a paired transcriptome/proteome time course dataset with 14 time points during Drosophila embryogenesis. Despite a limited mRNA-protein correlation (ρ = 0.54), mathematical models describing protein translation and degradation explain 84% of protein time-courses based on the measured mRNA dynamics without assuming complex post-transcriptional regulation, and allow for classification of most proteins into four distinct regulatory scenarios. By performing an in-depth characterization of the putatively post-transcriptionally regulated genes, we postulated that the RNA-binding protein Hrb98DE is involved in post-transcriptional control of sugar metabolism in early embryogenesis and partially validated this hypothesis using Hrb98DE knockdown. In summary, we present a systems biology framework for the identification of post-transcriptional gene regulation for large-scale time-resolved transcriptome and proteome data.

2018-10-26 | PXD011238 | Pride

Quantifying post-transcriptional regulation in the development of Drosophila melanogaster [s2r]

Project description:Proteome and transcriptome often show poor correlation, hindering the system-wide analysis of post-transcriptional regulation. Here, the authors study proteome and transcriptome dynamics during Drosophila embryogenesis and present basic mathematical models describing the temporal regulation of most protein-RNA pairs.

2018-10-13 | GSE121161 | GEO

Quantifying post-transcriptional regulation in the development of Drosophila melanogaster [devel]

2018-10-13 | GSE121160 | GEO

Quantifying post-transcriptional regulation in the development of Drosophila melanogaster.

Project description: Not available

| S-EPMC6255845 | biostudies-literature

Quantifying post-transcriptional regulation in the development of Drosophila melanogaster

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-10-13 | GSE121167 | GEO

Thermal acclimation in Drosophila melanogaster

Project description:Thermal acclimation study on Drosophila melanogaster reared at 3 different temperatures (12, 25, and 31oC). The proteomic profiles of D. melanogaster under these different temperatures were analyzed and compared using label-free tandem mass spectrometry.

2016-03-15 | PXD003755 | Pride