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Evaluating the effect of CovR phosphorylation on group A streptococcus global gene expression

ABSTRACT: Evaluating the effect of CovR phosphorylation on group A streptococcus global gene expression

PROVIDER: PRJNA497050 | ENA |

REPOSITORIES: ENA

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Evaluating the effect of CovR phosphorylation on group A streptococcus global gene expression

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Project description:We report the characterization of the major regulator of virulence gene expression (CovR) in Group B Streptococcus. The ChIP-seq experiments define the binding of CovR on the chromosome of the BM110 strain, a representative of the hypervirulent GBS lineage responsible of neonatal meningitis. Regulatory evolution of CovR signaling was investigated by comparing ChIP-seq done in parallel in a second GBS clinical isolate (NEM316) not belonging to the hypervirulent lineage.

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CovS Inactivation Reduces CovR Promoter Binding at Diverse Virulence Factor Encoding Genes in Group A Streptococcus

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