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VCRC Imaging Protocol for Magnetic Resonance and Positron Emission Tomography in Large-Vessel Vasculitis (Takayasu's Arteritis): Development as clinical trial outcome measures - VCRC 5515

ABSTRACT: VCRC Imaging Protocol for Magnetic Resonance and Positron Emission Tomography in Large-Vessel Vasculitis (Takayasu's Arteritis): Development as clinical trial outcome measures - VCRC 5515

PROVIDER: PRJNA497166 | ENA |

REPOSITORIES: ENA

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VCRC Imaging Protocol for Magnetic Resonance and Positron Emission Tomography in Large-Vessel Vasculitis (Takayasu's Arteritis): Development as clinical trial outcome measures - VCRC 5515

Project description:VCRC Imaging Protocol for Magnetic Resonance and Positron Emission Tomography in Large-Vessel Vasculitis (Takayasu's Arteritis): Development as clinical trial outcome measures - VCRC 5515

| PRJNA497165 | ENA

VCRC Longitudinal Protocol for Takayasu's Arteritis - VCRC 5503

Project description:VCRC Longitudinal Protocol for Takayasu's Arteritis - VCRC 5503

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VCRC Longitudinal Protocol for Polyarteritis Nodosa - VCRC 5504

Project description:VCRC Longitudinal Protocol for Polyarteritis Nodosa - VCRC 5504

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Comparison of magnetic resonance angiography and 18F-fluorodeoxyglucose positron emission tomography in large-vessel vasculitis.

Project description: Not available

| S-EPMC6045453 | biostudies-literature

VCRC Genetic Repository One-Time DNA Protocol - VCRC 5510

Project description:VCRC Genetic Repository One-Time DNA Protocol - VCRC 5510

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VCRC Longitudinal Protocol for Churg-Strauss Syndrome - VCRC 5506

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VCRC Longitudinal Protocol for Giant Cell Arteritis - VCRC 5502

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VCRC Genetic Repository One-Time DNA Protocol - VCRC 5510

Project description:VCRC Genetic Repository One-Time DNA Protocol - VCRC 5510

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18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers.

Project description:Fluorine-18-fluoro-2-deoxy-D-glucose (FDG) is widely used as positron-emission-tomography (PET) radiotracer for the detection and staging of human cancer. Tumor uptake of FDG varies substantially between different cancer types and between patients with the same tumor type. The molecular basis for this heterogeneity is unknown. Using cancer cell lines and primary human tumors of distinct histologic origins, we here show that increased FDG uptake is universally associated with coordinate upregulation of genes within the glycolysis, pentose-phosphate, and other related metabolic pathways. In primary human breast cancers, this FDG signature shows significant overlap with established breast cancer signatures for the “basal-like” disease subtype and “poor prognosis”. FDG high breast cancer showed significantly more gene copy number alterations genome wide than FDG low cancers. About 50 % of primary breast cancers with high FDG uptake and FDG gene expression signature show DNA copy gain encompassing the c-myc gene locus and express gene sets regulated by the transcription factor MYC. Our data shows that FDG-PET marks a distinct subset of “basal-like” human breast cancer which is characterized by MYC and prognostically unfavorable gene expression signatures, suggesting that FDG-PET imaging may be useful to risk-stratify patients with locally advanced breast cancer.

2011-11-01 | GSE21217 | GEO

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