Project description:To elucidate whether ZFP90 plays a role in colorectal cancer tumorigenesis, a RNA-seq analysis was performed to compare the gene expression profiles of ZFP90-KO and control Control cell.

2020-10-01 | GSE121621 | GEO

METTL3 promotes carcinogenesis in colorectal cancer

Project description:METTL3 promotes carcinogenesis in colorectal cancer

| PRJNA533611 | ENA

Fusobacterium nucleatum promotes colorectal carcinogenesis via an m6A dependent pathway

Project description:Previous reports have indicated that RNA m6A modification plays an important role in colorectal carcinogenesis. We hypothesized that F. nucleatum promoted colorectal carcinogenesis dependent on RNA m6A alterations. To test this hypothesis, we conducted a RNA-seq analysis in HT29 cells cocultured with F. nucleatum and medium control.

2022-12-01 | GSE191257 | GEO

PRSS8 Suppresses Colorectal Carcinogenesis and Metastasis.

Project description:PRSS8 Suppresses Colorectal Carcinogenesis and Metastasis.

| PRJNA475479 | ENA

FIBP maintains colorectal cancer cells stemness via demethylation of stemness genes

Project description:FIBP maintains colorectal cancer cells stemness via demethylation of stemness genes

| PRJNA412214 | ENA

ZFP90 drives initiation of colitis-associated colorectal cancer using a microbiota-dependent strategy

Project description:Chronic inflammation and gut microbiota dysbiosis are risk factors for colorectal cancer. In clinical practice, inflammatory bowel disease (IBD) patients have a greatly increased risk of developing colitis associated colorectal cancer (CAC). However, the basis underlying the initiation of CAC remains to be explored. Systematic filtration through existing genome-wide association study (GWAS) and conditional deletion of Zfp90 in CAC mice model indicated that Zfp90 was a putative oncogene in CAC development. Strikingly, depletion of gut microbiota eliminated the tumorigenic effect of Zfp90 in CAC mice model. Moreover, fecal microbiota transplantation demonstrated Zfp90 promoted CAC depending on gut microbiota. Combining 16s rDNA sequencing in feces specimens from CAC mice model, we speculated that Prevotella copri-defined microbiota might mediate the oncogenic role of Zfp90 in the development of CAC. Mechanistic studies revealed Zfp90 accelerated CAC development through Tlr4-Pi3k-Akt-Nf-κb pathway. Our findings elucidated the crucial role of Zfp90-microbiota-Nf-κb axis in creating a tumor-promoting environment and suggested therapeutic targets for CAC prevention and treatment.

2022-08-14 | GSE156241 | GEO

ZFP90 promotes colorectal carcinogenesis and stemness

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-10-01 | GSE121624 | GEO