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The in vitro effect of orexin A on the porcine myometrial transcriptomic profile during early-implantation period

ABSTRACT: The in vitro effect of orexin A on the porcine myometrial transcriptomic profile during early-implantation period

PROVIDER: PRJNA504628 | ENA |

REPOSITORIES: ENA

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The in vitro effect of orexin A on the porcine myometrial transcriptomic profile during early-implantation period

Project description:Orexins belong to the group of metabolism regulating factors connected mainly with the nervous system. Both biologically active neuropeptides, orexin A (OXA) and orexin B (OXB) are products of the proteolytic cleavage of common 130 amino-acid precursor – prepro-orexin (PPO). In the reproductive system orexins has been found to act not only on the endocrine, but also auto- and paracrine manner. In the present study we focused on the effect of OXA treatment on the global gene expression in the porcine myometrium during the most dynamic phase of the early pregnancy – the implantation period (days 15 to 16 of gestation).

2018-11-09 | GSE122310 | GEO

Transcriptomic analysis of the porcine anterior pituitary gland during the peri-implantation period

Project description:In pigs, the peri-implantation period is recognized as determinant of successful reproduction, and it is controlled by neuroendocrinal interactions among signals originating from the female hypothalamic-pituitary-ovarian axis, uterus, and developing embryo. The transcriptomic activity of the pituitary gland may influence reproductive processes occurring in pigs during the peri-implantation period. The aim of this study was to determine alternations in gene expression in the porcine pituitary gland during the peri-implantation period (days 15-16 of pregnancy) in comparison with that during the respective days of the estrous cycle using a microarray approach.

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The in vitro influence of orexin A on the porcine endometrium on days 15 to 16 of gestation.

Project description:Orexin A belongs to the group of hypothalamic-derived peptides that are involved in a number of processes, such as regulation of energy metabolism, control of food intake and regulation of the reproductive system. Orexin A is also expressed in the endometrium, myometrium and placenta, which suggests that it may act as an important local regulator of the reproductive functions. The aim of this study was to explore the influence of orexin A on global gene expression in the porcine endometrium during early gestation, on days 15 to 16 of pregnancy (implantation period).

2018-06-02 | GSE115195 | GEO

The in vitro influence of orexin B on the porcine myometrium on days 15 to 16 of gestation.

Project description:Orexin A (OXA) and orexin B (OXB) are hypothalamic-derived peptides that participate in the regulation of energy metabolism, food intake and reproductive function by influencing the hypothalamic-pituitary-ovarian axis. Orexins are also produced in the endometrium, myometrium and placenta, which suggests that they could act as a link between energy metabolism and the reproductive system. The aim of this study was to explore the influence of orexin B on global gene expression in the porcine myometrium during early gestation, on days 15 to 16 of pregnancy (implantation period).

2018-11-14 | GSE122414 | GEO

The in vitro influence of orexin B on the porcine endometrium on days 15 to 16 of gestation.

Project description:Orexins, namely orexin A (OXA) and orexin B (OXB) belongs to the family of neuropeptides produced mainly by specific neurons of the lateral region of the hypothalamus. Primarily orexins were recognized as hormones involved exclusively in the regulation of food intake and energy homeostasis. However, a growing body of evidences indicate their involvement in the regulation of an increasing number of biological processes, inter alia, in the regulation of the reproductive functions. The aim of this study was to explore the influence of orexin B on global gene expression in the porcine endometrium during early gestation, on days 15 to 16 of pregnancy (implantation period).

2018-11-14 | GSE122415 | GEO

microRNA expression profile in peri-implantation porcine embryos

Project description:Recently, microRNAs (miRNAs) have emerged as new players in the fine tuning of embryo development and implantation in mammals via posttranscriptional gene regulation mechanisms. Applying custom made multispecies arrays we aimed to analyze expression profile of microRNAs in peri-implantation porcine conceptuses/trophoblasts to identify their potential role at the maternal-fetal interface during the critical period of maternal recognition of pregnancy and implantation.

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microRNA expression profile in peri-implantation porcine embryos

2014-12-05 | E-GEOD-59618 | biostudies-arrayexpress

Transcriptomic analysis of the porcine anterior pituitary gland during the peri-implantation period

Project description:Transcriptomic analysis of the porcine anterior pituitary gland during the peri-implantation period

| PRJNA605556 | ENA

D11.5 Tubular Porcine Conceptus

Project description:Transcriptome profiling of in vivo-derived porcine conceptus at the tubular stage (12-80 mm) during the elongation period of peri-implantation development. Keywords: Embryo stage of development Transcriptome profiling of in vivo derivied porcine conceptuses at critical stages of pre-implantation development is being investigated to ascertain gene expression profiles associated with competent embryo development.

2005-12-30 | E-GEOD-3875 | biostudies-arrayexpress

D11.5 Tubular Porcine Conceptus

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