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Pituitary transcriptomic changes dependent on feed conversion in pigs

ABSTRACT: Pituitary transcriptomic changes dependent on feed conversion in pigs

PROVIDER: PRJNA504666 | ENA |

REPOSITORIES: ENA

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Pituitary transcriptomic changes dependent on feed conversion in pigs

Project description:Purpose: RNA-seq method was applied to select genes expressed in feed conversion in pigs and pinpointed genes potentially associated with this feature. Methods: The whole pituitary samples were collected from 16 Puławska pigs (8 pigs per two groups - with high and low feed conversion) maintained at the same environmental and feeding condition. The RNA-seq analysis was performed in 90 single-end cycles on HiScanSQ platform (Illumina) and differentially expressed genes (DEGs) were determined using Deseq2 software. Validation was performed for 10 randomly selected genes using real-time PCR method. Results: The study showed that in pigs characterized by better feed conversion 274 genes were differentially expressed. Genes showed decreased expression encode proteins associated with cholesterol metabolism (APOA1, CH25H, APOE) and regulation of hormone levels (POMC, CTSZ, ADM, AGTR1, SOX8, AGT, CPT1, APOA1, GJA1, MYRIP, CYP1B1, NR1D1). Four genes showed over the 10-fold decrease of expression (CRYM, ISM1 and WNK4), where the CRYM protein binds thyroid hormone for regulatory and developmental roles and WNK4 regulates the balance between NaCl reabsorption and K(+) secretion. In turn, genes showed an increase of expression in the pituitary of pigs having better feed conversion encode proteins were related to cellular response to corticotropin-releasing hormone stimulus (NR4A1, NR4A2, NR4A3) and regulation of type B pancreatic cell proliferation (BIRC5, NR4A3, NR4A1). Conclusions: The present study indicates new genes potentially related to feed conversion, which is one of the most economically important traits in pig breeding. The selected genes should be investigated in future in the terms of their association with fattening traits. The study was financed from funds of the project -BIOSTRATEG, the decision number BIOSTRATEG2/297267/14/NCBR/2016.

2018-11-12 | GSE122343 | GEO

The pituitary hormonal changes related to feed efficiency in pigs

Project description:In Poland, conducted for years porcine breeding works focused on improving meat content in the carcass without undertaken to accomplish the more effectiveness of fattening indicators that impact on feed efficiency. At present, feeding and feed conversion became important factors that are especially evident in the countries where the production of fattening pigs is conducted in large farms. In the present study, was attempted to indicate pituitary candidate genes depending on feed conversion ratio (FCR) in native Polish pig breed, Złotnicka White. The whole pituitary transcriptome was sequenced using next-generation sequencing technology. The obtained results show the differences in gene expression for pathways associated with hormonal regulation and also with Notch and Wnt signaling. Moreover, it was observed that worse FCR in Złotnicka pigs was associated with a higher fat level in a carcass and a significant higher level of prolactin expression in the pituitary.

2019-06-12 | GSE132522 | GEO

The pituitary hormonal changes related to feed efficiency in pigs

Project description:The pituitary hormonal changes related to feed efficiency in pigs

| PRJNA548282 | ENA

Hypothalamic transcriptome profiles of pigs divergent in feed efficiency

Project description:in vivo microarray study of transcriptional changes of the hypothalamus obtained from pigs divergent in feed efficiency.

2018-12-21 | GSE109334 | GEO

Ileal transcriptome profiles of pigs divergent in feed efficiency

Project description:in vivo microarray study of transcriptional changes of ileum (mucosa) obtained from pigs divergent in feed efficiency

2020-04-28 | GSE142434 | GEO

Caecal transcriptome profiles of pigs divergent in feed efficiency

Project description:in vivo microarray study of transcriptional changes of caecum (mucosa) obtained from pigs divergent in feed efficiency

2020-04-28 | GSE142433 | GEO

Ileal transcriptome profiles of pigs divergent in feed efficiency

Project description:in vivo microarray study of transcriptional changes of ileal scratchings (mucosa) obtained from pigs divergent in feed efficiency.

2018-12-21 | GSE109333 | GEO

Jejunal transcriptome profiles of pigs divergent in feed efficiency

Project description:in vivo microarray study of transcriptional changes of jejunal scratchings (mucosa) obtained from pigs divergent in feed efficiency.

2018-12-21 | GSE109332 | GEO

Duodenal transcriptome profiles of pigs divergent in feed efficiency

Project description:in vivo microarray study of transcriptional changes of duodenum scratchings (mucosa) obtained from pigs divergent in feed efficiency.

2018-12-21 | GSE109331 | GEO

Transcriptional patterns of pigs divergent in feed efficiency traits

Project description:in vivo microarray study to detect transcriptional changes in muscle tissue (M. longissimus) derived from pigs divergent in feed efficiency.

2017-12-22 | GSE99653 | GEO

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