Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The differentially expressed circular RNAs in the hippocampus of Nrf2-knockout mice

ABSTRACT: The differentially expressed circular RNAs in the hippocampus of Nrf2-knockout mice

PROVIDER: PRJNA505167 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

The differentially expressed circular RNAs in the hippocampus of Nrf2-knockout mice

Project description:Non-coding circular RNAs (circRNAs) have displayed dysregulated expression in the hippocampus of Nrf2-knockout mice.

2019-08-22 | GSE122421 | GEO

The differentially expressed circular and long non-coding RNAs in the prefrontal cortex of Nrf2-knockout mice

Project description:Circular RNAs (circRNAs), long non-coding RNAs (lncRNAs) and mRNAs have displayed dysregulated expression in the prefrontal cortex of Nrf2-knockout mice.

2020-12-01 | GSE162315 | GEO

The differentially long noncoding RNAs and mRNA in the hippocampus of Nrf2-knockout mice

Project description:Non-coding long noncoding RNAs (lncRNAs) and mRNA have displayed dysregulated expression in the hippocampus of Nrf2-knockout mice.

2019-08-22 | GSE122422 | GEO

The differentially long noncoding RNAs and mRNA in the hippocampus of Nrf2-knockout mice

Project description:The differentially long noncoding RNAs and mRNA in the hippocampus of Nrf2-knockout mice

| PRJNA505168 | ENA

The differentially expressed circular and long non-coding RNAs in the prefrontal cortex of Nrf2-knockout mice

Project description:The differentially expressed circular and long non-coding RNAs in the prefrontal cortex of Nrf2-knockout mice

| PRJNA681513 | ENA

Differential Expression Profiles and Functional Prediction of Circular RNAs and Long Non-coding RNAs in the Hippocampus of Nrf2-Knockout Mice.

Project description: Not available

| S-EPMC6697070 | biostudies-literature

seekCRIT: detecting and characterizing differentially expressed circular RNAs using high-throughput sequencing data

Project description:Recently, it has been demonstrated that genomes of many species express single stranded RNAs with covalently closed ends, named circular RNAs. Their regulatory potential and functional relevance are just starting to be revealed. Here we present a novel computational tool, seekCRIT (seek for differentially expressed Circular RNAs In Transcriptome), that identifies circular RNAs and detects their differential expression between two conditions. Using seekCRIT we identified the circular RNAs that are expressed in the neural retina and determined that the majority of them (74%) are expressed in both, ischemic and normal conditions. We identified over 40 circular RNAs that were differentially expressed between both conditions and validated these experimentally using qRT-PCR. The high validation rate of 90% with a false discovery rate (FDR) of < 5% demonstrates the accuracy and reliability of seekCRIT.

2021-02-02 | GSE114896 | GEO

Differentially expressed circular RNAs in a murine asthma model.

Project description: Not available

| S-EPMC7647044 | biostudies-literature

Transcriptomics Analysis of Circular RNAs Differentially Expressed in Apoptotic HeLa Cells.

Project description: Not available

| S-EPMC6424894 | biostudies-literature

Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed

Project description:Circular RNAs (circRNAs) are an endogenous class of animal RNAs. Despite their abundance, their function and expression in the nervous system are unknown. Therefore, we sequenced RNA from different brain regions, primary neurons, isolated synapses, as well as during neuronal differentiation. Using these and other available data, we discovered and analyzed thousands of neuronal human and mouse circRNAs. circRNAs were extraordinarily enriched in the mammalian brain, well conserved in sequence, often expressed as circRNAs in both human and mouse, and sometimes even detected in Drosophila brains. circRNAs were overall upregulated during neuronal differentiation, highly enriched in synapses, and often differentially expressed compared to their mRNA isoforms. circRNA expression correlated negatively with expression of the RNA-editing enzyme ADAR1. Knockdown of ADAR1 induced elevated circRNA expression. Together, we provide a circRNA brain expression atlas and evidence for important circRNA functions and values as biomarkers. To assess circRNA expression in mammalian brain, we sequenced and analyzed mouse brain regions (hippocampus, cerebellum, prefrontal cortex and olfactory bulb), various neuronal differentiation (mouse P19 and human SH-SY5Y cells) and maturation (mouse cortical neurons) stages, and subcellular compartments in mouse (synaptoneurosomal fraction, cytoplasmic fraction, whole brain lysate).

2015-04-24 | E-GEOD-65926 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data