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Mediator12 and 13 act as conditional anti-silencing factors in Arabidopsis [RNA-seq]

ABSTRACT: Mediator12 and 13 act as conditional anti-silencing factors in Arabidopsis [RNA-seq]

PROVIDER: PRJNA509225 | ENA |

REPOSITORIES: ENA

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Mediator12 and 13 act as conditional anti-silencing factors in Arabidopsis

Project description:Mediator12 and 13 act as conditional anti-silencing factors in Arabidopsis

| PRJNA509224 | ENA

Mediator12 and 13 act as conditional anti-silencing factors in Arabidopsis [ChIP-seq]

Project description:Mediator12 and 13 act as conditional anti-silencing factors in Arabidopsis [ChIP-seq]

| PRJNA509226 | ENA

Mediator12 and 13 act as conditional anti-silencing factors in Arabidopsis [ChIP-seq]

2020-12-31 | GSE123562 | GEO

Mediator12 and 13 act as conditional anti-silencing factors in Arabidopsis [RNA-seq]

2020-12-31 | GSE123561 | GEO

Mediator12 and 13 act as conditional anti-silencing factors in Arabidopsis

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-12-31 | GSE123563 | GEO

The characterization of Mediator12 and 13 as conditional positive gene regulators in Arabidopsis

Project description:The characterization of Mediator12 and 13 as conditional positive gene regulators in Arabidopsis

| PRJNA601786 | ENA

The characterization of Mediator12 and 13 as conditional positive gene regulators in Arabidopsis [ChIP-seq]

Project description:The characterization of Mediator12 and 13 as conditional positive gene regulators in Arabidopsis [ChIP-seq]

| PRJNA601783 | ENA

The characterization of Mediator12 and 13 as conditional positive gene regulators in Arabidopsis [RNA-seq]

Project description:The characterization of Mediator12 and 13 as conditional positive gene regulators in Arabidopsis [RNA-seq]

| PRJNA601788 | ENA

The characterization of Mediator12 and 13 as conditional positive gene regulators in Arabidopsis

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-04-29 | GSE143835 | GEO

The characterization of Mediator12 and 13 as conditional positive gene regulators in Arabidopsis [RNA-seq]

Project description:Mediator is a multi-protein complex which facilitates the initial steps of gene transcription. Mediator 12 (MED12) and MED13 are components of a module that reversibly associates with the core Mediator complex, and both positively and negatively regulates gene expression. Here, in an Arabidopsis mutant screen for factors required for morc1 de-repressed gene expression, we identified MED12 and MED13 as positive gene regulators, both of which contribute broadly to morc1 de-repressed gene expression. Both MED12 and MED13 are preferentially required for the expression of genes lacking active chromatin marks, a chromatin signature shared with morc1 re-activated loci. We further discovered that MED12 tends to interact with genes that are responsive to environmental stimuli, including light and radiation. We demonstrate that the light-induced transient gene expression depends on MED12, and is accompanied by a concomitant increase in MED12 enrichment during induction. In contrast, the steady-state expression level of these genes showed little dependence on MED12, suggesting that MED12 is primarily required to aid the expression of genes in transition from non-active to active states.

2020-04-29 | GSE143833 | GEO

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