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Intergenerational transmission of the positive effects of physical exercise on brain and cognition

ABSTRACT: Intergenerational transmission of the positive effects of physical exercise on brain and cognition

PROVIDER: PRJNA509258 | ENA |

REPOSITORIES: ENA

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Transgenerational effects of exercise on mouse brain and cognition

Project description:Lifestyle induces long lasting effects on the brain and cognition, with some interventions like stress including transgenerational inheritance on the next generations mediated by epigenetic mechanisms. Physical exercise is one potent intervention driving robust improvements of cognition and brain health, also inducing intergenerational transmission to the litter. However, little is known about whether exercise effects may be transgenerationally transmitted. Here we analyzed the adult hippocampal neurogenesis (AHN) and the behavioral phenotype of sedentary adult male mice of the F2 generation of exercised grandfathers (F0, patrilineal design). Both F1 and F2 were sedentary, while F0 performed a moderate exercise training. We found that the F2 mice from exercised F0 acquired and recalled both spatial and non-spatial information better than F2 from sedentary F0. Contextual fear conditioning resulted not affected, together with no differences in the AHN markers. These results demonstrate that the transgenerational transmission of the effects of exercise on specific cognitive tasks persists after two generations, even though some of the cellular changes induced in F1 disappear in F2, and suggest that moderate exercise training has a longer-lasting effect than previously thought, and this aspect is worth taking into account in public health programs.

2024-06-12 | GSE217487 | GEO

Intergenerational transmission of the positive effects of physical exercise on brain and cognition

Project description:Parental moderate exercise induces positive effects on sedentary litter’s behavior, and on hippocampal gene expression, adult neurogenesis and mitochondrial activation

2019-04-16 | GSE123582 | GEO

Intergenerational transmission of the positive effects of physical exercise on brain and cognition.

Project description: Not available

| S-EPMC6525532 | biostudies-literature

Sequencing of Nothobranchius fuzeri (strain: GRZ) skin after physical exercise

Project description:Comparison of gene expression profiles from Nothobranchius furzeri (strain: GRZ) skin after physical exercise. For physical exercise, fish were placed in swim-tunnel for 4 weeks and were swimming 6 times per day for 5 min duration (water velocity 14 cm/s). The RNA-seq data comprise 10 samples. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE103818 | GEO

Sequencing of Nothobranchius fuzeri muscle (strain: GRZ) after physical exercise

Project description:Comparison of gene expression profiles from Nothobranchius furzeri (strain: GRZ) muscle after physical exercise. For physical exercise, fish were placed in swim-tunnel for 4 weeks and were swimming 6 times per day for 5 min duration (water velocity 14 cm/s). The RNA-seq data comprise 10 samples. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE103815 | GEO

Sequencing of Nothobranchius fuzeri (strain: GRZ) liver after physical exercise

Project description:Comparison of gene expression profiles from Nothobranchius furzeri (strain: GRZ) liver after physical exercise. For physical exercise, fish were placed in swim-tunnel for 4 weeks and were swimming 6 times per day for 5 min duration (water velocity 14 cm/s). The RNA-seq data comprise 10 samples. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE103808 | GEO

Sequencing of Nothobranchius fuzeri (strain: GRZ) brain after physical exercise

Project description:Comparison of gene expression profiles from Nothobranchius furzeri (strain: GRZ) brain after physical exercise. For physical exercise, fish were placed in swim-tunnel for 4 weeks and were swimming 6 times per day for 5 min duration (water velocity 14 cm/s). The RNA-seq data comprise 10 samples. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE103803 | GEO

Sequencing of Mus musculus hemisphere after physical exercise at two different ages

Project description:Comparison of gene expression profiles from Mus musculus cerebral hemisphere after physical exercise (treadmill; endurance training over 4 weeks). The RNA-seq data comprise4 groups: 2 age groups, each w/ and w/o physical exercise. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE111214 | GEO

Sequencing of Mus musculus hippocampus after physical exercise at two different ages

Project description:Comparison of gene expression profiles from Mus musculus hippocampus after physical exercise (treadmill; endurance training over 4 weeks). The RNA-seq data comprise 4 groups: 2 age groups, each w/ and w/o physical exercise. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE111212 | GEO

Sequencing of Mus musculus muscle after physical exercise in C57BL/6 and NRF2-KO

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2021-10-19 | GSE110850 | GEO

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