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Transcription factor C/EBPβ orchestrates DC maturation and functionality under homeostatic and malignant conditions

ABSTRACT: Transcription factor C/EBPβ orchestrates DC maturation and functionality under homeostatic and malignant conditions

PROVIDER: PRJNA509273 | ENA |

REPOSITORIES: ENA

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Transcription factor C/EBPβ orchestrates DC maturation and functionality under homeostatic and malignant conditions [CEBPbetaKO]

Project description:Dendritic cell (DC) maturation is a prerequisite for the induction of adaptive immune responses against pathogens and cancer. Transcription factor (TF) networks control differential aspects of early DC progenitor versus late stage DC cell fate decisions. Here, we identified the TF C/EBPβ as a key regulator for DC maturation and immunogenic functionality under homeostatic and lymphoma-transformed conditions. Gene expression profiles of splenic C/EBPβ-/- DCs showed a strong downregulation of E2F cell cycle target genes, whereas signatures of maturation were enriched. In accordance with E2F1 being a negative regulator of DC maturation, C/EBPβ-/- bone marrow-derived DCs matured much faster enabling them to strongly activate T cells. Conversely, the E2F transcriptional pathways were upregulated in lymphoma-exposed DCs and DC maturation was impaired. Pharmacological blockade of C/EBPβ/mTOR signaling in human DCs abrogated their pro-tumorigenic function in B-cell lymphoma co-cultures. Thus, C/EBPβ plays a unique role in DC maturation and functionality and emerges as a key factor of the microenvironment promoting lymphomagenesis.

2020-10-20 | GSE123591 | GEO

Transcription factor C/EBPβ orchestrates DC maturation and functionality under homeostatic and malignant conditions [Emu-Myc]

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Transcription factor C/EBPβ orchestrates DC maturation and functionality under homeostatic and malignant conditions [CEBPbetaKO]

Project description:Transcription factor C/EBPβ orchestrates DC maturation and functionality under homeostatic and malignant conditions [CEBPbetaKO]

| PRJNA509277 | ENA

Transcription factor C/EBPβ orchestrates DC maturation and functionality under homeostatic and malignant conditions [Emu-Myc]

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Transcription factor C/EBPβ orchestrates DC maturation and functionality under homeostatic and malignant conditions

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-10-20 | GSE123593 | GEO

The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.

Project description: Not available

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Compartment-specific regulation of gene expression orchestrates homeostatic synaptic scaling

Project description:Compartment-specific regulation of gene expression orchestrates homeostatic synaptic scaling

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Project description:Global transcriptional analysis was used in order to understand functionality and applicability of in vitro DC models.

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Project description:To characterize genome-wide C/EBPβ traget genes in C/EBPβ-overexpressed HL-60 cells by ChIP-seq.

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