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Gene expression profiling in Hepa1c1c7 transfected Cd74 or Tmem54.

ABSTRACT: Gene expression profiling in Hepa1c1c7 transfected Cd74 or Tmem54.

PROVIDER: PRJNA509661 | ENA |

REPOSITORIES: ENA

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Gene expression profiling in Hepa1c1c7 transfected Cd74 or Tmem54.

Project description:To analyse Cd74 and Tmem54 function as tumor associated genes, we carried out overexpression analysis of Cd74 or Tmem54 using Hepa1c1c7 and investigated downstream genes expression by microarray.

2019-08-20 | GSE123718 | GEO

Gene Expression Profiling in Normal Tissue and Tumor Tissue From Patients With Colon Cancer That Has Spread to the Liver, Lungs, or Peritoneum

Project description:RATIONALE: Studying the genes expressed in samples of tissue from patients with cancer may help doctors identify biomarkers related to cancer. PURPOSE: This laboratory study is using gene expression profiling to evaluate normal tissue and tumor tissue from patients with colon cancer that has spread to the liver, lungs, or peritoneum.

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CD74-NRG1 fusions in lung adenocarcinoma

Project description:We discovered a novel somatic gene fusion, CD74-NRG1, by transcriptome sequencing of 25 lung adenocarcinomas of never smokers. By screening 102 lung adenocarcinomas negative for known oncogenic alterations we found four additional fusion-positive tumors, all of which were of the invasive mucinous subtype. Mechanistically, CD74-NRG1 leads to extracellular expression of the EGF-like domain of NRG1 III-beta3, thereby providing the ligand for ERBB2-ERBB3 receptor complexes. Accordingly, ERBB2 and ERBB3 expression was high in the index case and expression of phospho-ERBB3 was specifically found in tumors bearing the fusion (p<0.0001). Ectopic expression of CD74-NRG1 in lung cancer cell lines expressing ERBB2 and ERBB3 activated ERBB3 and the PI3K-AKT pathway, and led to increased colony formation in soft agar. Thus, CD74-NRG1 gene fusions are activating genomic alterations in invasive mucinous adenocarcinomas and may offer a therapeutic opportunity for a lung tumor subtype with, so far, no effective treatment.

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CD74 downregulation in placental macrophages and its influence on trophoblast cells.

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