Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The single cell transcriptional landscape of human lung adenocarcinoma (primary tumours and metastases)

ABSTRACT: The single cell transcriptional landscape of human lung adenocarcinoma (primary tumours and metastases)

PROVIDER: PRJNA510251 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

The single cell transcriptional landscape of human lung adenocarcinoma (primary tumours and metastases)

Project description:By transcriptionally profiling single cells from patients spanning different stages of lung adenocarcinoma progression, we provide evidence of epithelial regeneration in untreated primary tumours and a continuum of phenotypic states spanning key stages of embryonic development and lung morphogenesis in metastases. We transcriptionally profiled 41,384 single cells obtained from fresh surgical human samples taken from non-tumour-involved lung (n = 4), primary lung adenocarcinomas (n = 8; 7 untreated and 1 post neo-adjuvant chemotherapy), as well as brain (n = 3), bone (n = 1), and adrenal (n = 1) lung adenocarcinoma metastases. These samples were derived from patients spanning various stages of tumour progression without enrichment for a specific cell type, such that the entire tumour and its microenvironment were sampled in an unbiased manner. Data from all patients were merged to create a global cell atlas of the normal lung, primary tumours, and metastases.

2020-01-14 | GSE123902 | GEO

miRNA sequence analysis of primary lesions, brain metastases, and normal lung tissues in lung adenocarcinoma

Project description:We obtained primary lesions, brain metastases, and normal lung tissues from lung adenocarcinoma patients. Next generation sequencing was performed to assess the expressions of miRNA in these specimens.

2023-04-26 | GSE230229 | GEO

Transcriptomic profiling and analyses of murine primary prostate tumours and metastases

Project description:RNA was extracted from the frozen localised prostate tumour (primary prostate tumours), proximal (epididymal fat) and distal (lung) metastases from Ctnnb1pc(ex3)Δ/+ Ptenpc+/- (n=3 matched; ~9-10 months)

2022-08-20 | GSE136082 | GEO

Methylation data of 20 samples of human lung adenocarcinoma brain metastases

Project description:Methylation status of lung adenocarcinoma brain metastases was analyzed as part of an approach to defining the microenvironment

2020-01-04 | E-MTAB-8660 | biostudies-arrayexpress

mRNA microarray data of 63 samples of human lung adenocarcinoma brain metastases

Project description:mRNA expression of lung adenocarcinoma brain metastases was analyzed as part of an approach to defining the microenvironment

2020-01-03 | E-MTAB-8659 | biostudies-arrayexpress

The Rapid Autopsy Tissue Proteomic Landscape of Pancreatic Ductal Adenocarcinoma Liver Metastases and its Correlation with Patients’ Profile, Treatments and Outcome

Project description:The goal of the experiment was to explore the differences in the proteomic landscape of pancreatic cancer tissues collected by the Rapid Autopsy Program at UNMC. We hypothesized the proteomic profile can reflect some of the clinical features observed in the patient, and such information can be used for the diagnosis of the disease, or assisting in the selection of treatment options in a clinical setting. The liver metastases tissue collected from 59 pancreatic cancer patients were used to explore the proteomic landscape. 56 of these patients were diagnosed with pancreatic ductal adenocarcinoma (PDAC) and 3 of them had pancreatic neuroendocrine tumors (PanNET).

2019-11-18 | PXD012173 | Pride

The Rapid Autopsy Tissue Proteomic Landscape of Pancreatic Ductal Adenocarcinoma Liver Metastases and its Correlation with Patients’ Profile, Treatments and Outcome (supplementary data)

2019-11-18 | PXD015492 | Pride

Altered 5-hydroxymethylcytosine landscape in primary gastric adenocarcinoma

Project description:Altered 5-hydroxymethylcytosine landscape in primary gastric adenocarcinoma

| PRJNA556817 | ENA

KP lung tumours

Project description:KP lung tumours

| PRJNA577056 | ENA

Proteomic changes between primary tumors and matched distant metastases of lung adenocarcinomas

Project description:Lung cancer is the leading cause of cancer-related deaths worldwide and lung adenocarcinoma is the most common form of lung cancer. Genomic studies of lung adenocarcinoma (LUAD) have advanced our understanding of the disease's biology and accelerated targeted therapy. However, the proteomic characteristics of LUAD are still insufficiently understood. Prognosis for lung cancer patients remains poor and is strongly related to the stage of disease at the time of diagnosis. Therefore, our study focuses on metastasis formation in LUAD. We performed high-performance liquid chromatography (HPLC) and electrospray ionization tandem mass spectrometry (ESI-MS/MS) on a total of 40 FFPE samples and compared proteomic profiles of primary tumors to those of matched distant metastases. Using differential expression analysis and unsupervised clustering we identified candidate proteins playing a role in metastatic spread. Selected proteins were validated by immunoblotting. Our findings give a better understanding of tumor progression and metastasis formation in LUAD and might help to develop biomarker specific therapy.

2023-11-28 | PXD042604 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data