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Basic characteristics of glioma stem cell and human glioblastoma

ABSTRACT: Basic characteristics of glioma stem cell and human glioblastoma



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Basic Gene Expression Characteristics of Glioma Stem Cells and Human Glioblastoma.

Sakamoto Daisuke D   Takagi Toshinori T   Fujita Mitsugu M   Omura Seiichi S   Yoshida Yasunori Y   Iida Tomoko T   Yoshimura Shinichi S  

Anticancer research 20190201 2

BACKGROUND:Glioma stem cells (GSCs) play important roles in the tumorigenesis of glioblastoma multiforme (GBM). Using a novel cellular bioinformatics pipeline, we aimed to characterize the differences in gene-expression profiles among GSCs, U251 (glioma cell line), and a human GBM tissue sample. MATERIALS AND METHODS:Total RNA was extracted from GSCs, U251 and GBM and microarray analysis was performed; the data were then applied to the bioinformatics pipeline consisting of a principal component  ...[more]

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