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Cryptochromes-mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved signaling mechanism

ABSTRACT: Cryptochromes-mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved signaling mechanism

PROVIDER: PRJNA511889 | ENA |

REPOSITORIES: ENA

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Cryptochromes-mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved signaling mechanism

Project description:Purpose: The goal of this study is to analyze the Cryptochrome-Cop1 axis in mammals Methods: mouse embryonic fibroblasts treated with dexamethasone, KL001 and/or Cop1 knockdown. Results: The transcriptomic analysis helps us to support our finding that the Cryptochromes-dependent repression of the glucocorticoid receptor is mediated by Cop1.

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Identification of evolutionary conserved gene networks that mediate neurodegenerative dementia

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A novel evolutionary conserved mechanism of RNA stability regulates synexpression of primordial germ cell-specific genes prior to the sex-determination stage

Project description:Dmrt1 is a highly conserved transcription factor, which is critically involved in regulation of gonad development of vertebrates. In medaka a duplicate of dmrt1, acting as master sex-determining gene, has a tightly timely and locally patterned gonadal expression pattern. In addition to transcriptional regulation, a sequence motif in the 3’ UTR (D3U-box) was shown to mediate transcript stability of dmrt1 mRNAs from medaka and other vertebrates. We show here that in medaka two RNA-binding proteins with antagonizing properties competitively target this D3U-box, promoting either RNA stabilization in germ cells or degradation in the soma. Such evolutionary conservation of the D3U-box motif within the dmrt1 genes and among genomes of metazoans together with preserved expression patterns of the targeting RNA binding proteins in subsets of germ cells, suggest this new mechanism for controlling RNA stability is not restricted to fishes, but might also apply to other vertebrates.

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