Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Limosilactobacillus fermentum isolate:Lactobacillus fermentum | breed:procaryotic breed | cultivar:Bacilli

ABSTRACT: Lactobacillus fermentum

PROVIDER: PRJNA512214 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Limosilactobacillus fermentum Limits Candida glabrata Growth by Ergosterol Depletion

Project description:Candida glabrata is a human-associated opportunistic fungal pathogen. It shares its niche with Lactobacillus spp. in the gastrointestinal and vaginal tract. In fact, Lactobacillus species are thought to competitively prevent Candida overgrowth. We investigated the molecular aspects of this antifungal effect by analyzing the interaction of C. glabrata strains with Limosilactobacillus fermentum. From a collection of clinical C. glabrata isolates, we identified strains with different sensitivities to L. fermentum in coculture. We analyzed the variation of their expression pattern to isolate the specific response to L. fermentum. C. glabrata-L. fermentum coculture induced genes associated with ergosterol biosynthesis, weak acid stress, and drug/chemical stress. L. fermentum coculture depleted C. glabrata ergosterol. The reduction of ergosterol was dependent on the Lactobacillus species, even in coculture with different Candida species. We found a similar ergosterol-depleting effect with other lactobacillus strains (Lactobacillus crispatus and Lactobacillus rhamosus) on Candida albicans, Candida tropicalis, and Candida krusei. The addition of ergosterol improved C. glabrata growth in the coculture. Blocking ergosterol synthesis with fluconazole increased the susceptibility against L. fermentum, which was again mitigated by the addition of ergosterol. In accordance, a C. glabrata Derg11 mutant, defective in ergosterol biosynthesis, was highly sensitive to L. fermentum. In conclusion, our analysis indicates an unexpected direct function of ergosterol for C. glabrata proliferation in coculture with L. fermentum.

2023-02-08 | GSE202656 | GEO

Total RNAseq of Lactobacillus fermentum

Project description:We applied total RNA sequencing of Lactobacillus fermentum strain GR1008 and GR1009 and compare the differentially expressed genes. This study aimed to find out the underlying mechanims for the differential morphology of the two strains.

2022-10-14 | GSE186000 | GEO

Effects of two strains of Lactobacillus fermentum on germ free rats

Project description:Transcription profiling of intestinal tissue from germ free rats mono-colonised with one of two strains of Lactobacillus fermentum; AGR1485 or AGR 1487

2014-06-25 | GSE58777 | GEO

Limosilactobacillus fermentum isolate:LF | breed:prokaryote | cultivar:Lactobacillus

Project description:Limosilactobacillus fermentum isolate:LF | breed:prokaryote | cultivar:Lactobacillus Raw sequence reads

| PRJNA512219 | ENA

Effects of two strains of Lactobacillus fermentum on germ free rats

Project description:Transcription profiling of intestinal tissue from germ free rats mono-colonised with one of two strains of Lactobacillus fermentum; AGR1485 or AGR 1487 Two colour microarray, reference design. 2 treatments (AGR1485 or AGR1487) and 2 tissues analysed (colon or duodenum): Biological replicates: 6

2014-06-25 | E-GEOD-58777 | biostudies-arrayexpress

Limosilactobacillus fermentum

Project description:Lactobacillus fermentum 01-B1, complete sequence

| PRJDB11003 | ENA

Limosilactobacillus fermentum

Project description:Lactobacillus fermentum CBA7106 Genome sequencing and assembly

| PRJNA390215 | ENA

Limosilactobacillus fermentum strain:PV22

Project description:Antiviral Lactobacillus fermentum Assembly

| PRJNA703332 | ENA

Limosilactobacillus fermentum strain:AGR1487

Project description:Lactobacillus fermentum strain AGR1487