Genomics

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DENR-regulated reinitiation events uncover predictive uORF features and links to circadian timekeeping via Clock regulation


ABSTRACT: DENR-regulated reinitiation events uncover predictive uORF features and links to circadian timekeeping via Clock regulation

PROVIDER: PRJNA513490 | ENA |

REPOSITORIES: ENA

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Charting DENR-dependent translation reinitiation uncovers predictive uORF features and links to circadian timekeeping via Clock.

Castelo-Szekely Violeta V   De Matos Mara M   Tusup Marina M   Pascolo Steve S   Ule Jernej J   Gatfield David D  

Nucleic acids research 20190601 10


The non-canonical initiation factor DENR promotes translation reinitiation on mRNAs harbouring upstream open reading frames (uORFs). Moreover, DENR depletion shortens circadian period in mouse fibroblasts, suggesting involvement of uORF usage and reinitiation in clock regulation. To identify DENR-regulated translation events transcriptome-wide and, in particular, specific core clock transcripts affected by this mechanism, we have used ribosome profiling in DENR-deficient NIH3T3 cells. We uncover  ...[more]

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