Genomics

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Single-cell RNA sequencing of BCSCs from solid tumors taken from NOD/SCID mice


ABSTRACT: Single-cell RNA sequencing of BCSCs from solid tumors taken from NOD/SCID mice

PROVIDER: PRJNA514089 | ENA |

REPOSITORIES: ENA

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Quiescent cancer stem cells (CSC) play important roles in tumorigenesis, relapse, and resistance to chemoradiotherapy. However, the determinants of CSC quiescence and how they sustain themselves to generate tumors and relapse beyond resistance to chemoradiotherapy remains unclear. Here, we found that SET domain-containing protein 4 (SETD4) epigenetically controls breast CSC (BCSC) quiescence by facilitating heterochromatin formation via H4K20me3 catalysis. H4K20me3 localized to the promoter regi  ...[more]

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