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Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes

ABSTRACT: Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes

PROVIDER: PRJNA515324 | ENA |

REPOSITORIES: ENA

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Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [expression array]

Project description:In this study, use of a gene-targeted mouse model that is defective for pRb-condensin II interactions, Rb1L, has revealed instances where condensin II localization in interphase nuclei is dependent on pRb. Condensin II binding overlaps significantly with marks of active chromatin, and is enriched at the promoters of genes, including closely spaced divergent promoters. Interestingly, there are some bidirectional promoters where condensin II binds in an pRb-dependent manner and transcription of only one of the two genes is upregulated in Rb1L/L MEFs, suggesting the pRb-condensin II complex may be acting as a repressor or an insulator at distinct genomic locations to influence transcription. Chromatin conformations at these locations demonstrated that the pRb-condensin II complex may be responsible for maintaining more static, long-range interactions. In addition, pRb also recruits TFIIIC, another condensin II interactor, to many genomic loci. These recently discovered non-canonical transcriptional functions of the pRb-condensin II complex may represent an additional mechanism of pRb-mediated tumor suppression.

2019-11-04 | GSE125148 | GEO

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [RNA-seq]

2019-11-04 | GSE125147 | GEO

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [ChIP-seq]

2019-11-04 | GSE125139 | GEO

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [4C-seq]

2019-11-04 | GSE125127 | GEO

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [RNA-seq]

Project description:Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [RNA-seq]

| PRJNA515327 | ENA

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [4C-seq]

Project description:Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [4C-seq]

| PRJNA515313 | ENA

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [ChIP-seq]

Project description:Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [ChIP-seq]

| PRJNA515322 | ENA

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [expression array]

Project description:Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [expression array]

| PRJNA515326 | ENA

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-11-04 | GSE125149 | GEO

Transcription-associated Loading of Condensin II on Chromosome Arms in Embryonic Stem Cells (nocodazole ChIP-Seq)

Project description:Vertebrate condensin I and II molecules are loaded onto the genome to mediate essential changes in chromosome condensation during mitosis, but it is not clear how the two forms of condensin become distributed on chromosomes. We report here that condensin II, the form of condensin present in the nucleus throughout the cell cycle, is loaded at transcriptionally active promoters, migrates through these genes in a transcription-dependent fashion and accumulates in transcription termination regions during interphase. During mitosis, condensin I is recruited to actively transcribed genes and replaces condensin II. We conclude that the two forms of condensin are loaded at different times during the cell division cycle at the promoters of actively transcribed genes. ChIP-Seq data for Condensin II in v6.5 ESCs treated or not with nocodazole

2012-03-14 | E-GEOD-33346 | biostudies-arrayexpress

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